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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Prange-kiel, Janine Zhou, Lepu Rune, Gabriele M. Jarry, Hubertus Schoen, Michael Kohlmann, Patrick Lohse, Christina |
| Description | Author Affiliation: Prange-Kiel J ( Institute of Anatomy I: Cellular Neurobiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. prange-kiel@uke.uni-hamburg.de) |
| Abstract | Spine density in the hippocampus changes during the estrus cycle and is dependent on the activity of local aromatase, the final enzyme in estrogen synthesis. In view of the abundant gonadotropin-releasing hormone receptor (GnRH-R) messenger RNA expression in the hippocampus and the direct effect of GnRH on estradiol (E2) synthesis in gonadal cells, we asked whether GnRH serves as a regulator of hippocampal E2 synthesis. In hippocampal cultures, E2 synthesis, spine synapse density, and immunoreactivity of spinophilin, a reliable spine marker, are consistently up-regulated in a dose-dependent manner at low doses of GnRH but decrease at higher doses. GnRH is ineffective in the presence of GnRH antagonists or aromatase inhibitors. Conversely, GnRH-R expression increases after inhibition of hippocampal aromatase. As we found estrus cyclicity of spine density in the hippocampus but not in the neocortex and GnRH-R expression to be fivefold higher in the hippocampus compared with the neocortex, our data strongly suggest that estrus cycle–dependent synaptogenesis in the female hippocampus results from cyclic release of GnRH. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 2 |
| Volume Number | 180 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2008-01-28 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Estradiol Biosynthesis Gonadotropin-Releasing Hormone Metabolism Hippocampus Animals Estrus Genetics Microfilament Proteins Nerve Tissue Proteins RNA, Messenger Rats, Wistar Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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