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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Liu, Fangfang Ng, Seng Kah Lai, Julian Jedd, Gregory Lu, Yanfen Low, Wilson |
| Description | Author Affiliation: Liu F ( Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore.) |
| Abstract | Woronin bodies (WBs) are dense-core organelles that are found exclusively in filamentous fungi and that seal the septal pore in response to wounding. These organelles consist of a membrane-bound protein matrix comprised of the HEX protein and, although they form from peroxisomes, their biogenesis is poorly understood. In Neurospora crassa, we identify Woronin sorting complex (WSC), a PMP22/MPV17-related membrane protein with dual functions in WB biogenesis. WSC localizes to large peroxisome membranes where it self-assembles into detergent-resistant oligomers that envelop HEX assemblies, producing asymmetrical nascent WBs. In a reaction requiring WSC, these structures are delivered to the cell cortex, which permits partitioning of the nascent WB and WB inheritance. Our findings suggest that WSC and HEX collaborate and control distinct aspects of WB biogenesis and that cortical association depends on WSC, which in turn depends on HEX. This dependency helps order events across the organellar membrane, permitting the peroxisome to produce a second organelle with a distinct composition and intracellular distribution. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 2 |
| Volume Number | 180 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2008-01-28 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Hyphae Cytology Neurospora Crassa Metabolism Organelles Peroxisomes Amino Acid Sequence Fungal Proteins Molecular Sequence Data Mutation Genetics Phylogeny Protein Transport Sequence Alignment Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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