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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Romagnolo, Béatrice Gerbe, François Pignodel, Christine Bourgaux, Jean-françois Clevers, Hans Jay, Philippe Makrini, Leila Brulin, Bénédicte Robine, Sylvie Van Es, Johan H. Mellitzer, Georg Shroyer, Noah F. |
| Description | Author Affiliation: Gerbe F ( CNRS UMR5203, Montpellier F-34094, France.) |
| Abstract | The unique morphology of tuft cells was first revealed by electron microscopy analyses in several endoderm-derived epithelia. Here, we explore the relationship of these cells with the other cell types of the intestinal epithelium and describe the first marker signature allowing their unambiguous identification. We demonstrate that although mature tuft cells express DCLK1, a putative marker of quiescent stem cells, they are post-mitotic, short lived, derive from Lgr5-expressing epithelial stem cells, and are found in mouse and human tumors. We show that whereas the ATOH1/MATH1 transcription factor is essential for their differentiation, Neurog3, SOX9, GFI1, and SPDEF are dispensable, which distinguishes these cells from enteroendocrine, Paneth, and goblet cells, and raises from three to four the number of secretory cell types in the intestinal epithelium. Moreover, we show that tuft cells are the main source of endogenous intestinal opioids and are the only epithelial cells that express cyclooxygenase enzymes, suggesting important roles for these cells in the intestinal epithelium physiopathology. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 5 |
| Volume Number | 192 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2011-03-07 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Basic Helix-Loop-Helix Transcription Factors Metabolism Intestinal Mucosa Cytology Nerve Tissue Proteins Adenocarcinoma Pathology Adenoma Animals Genetics Physiology Biological Markers Cell Differentiation Cyclooxygenase 1 Cyclooxygenase 2 Intestinal Neoplasms Intestine, Large Intestine, Small Isomerases Membrane Proteins Mice Mice, Inbred C57BL Protein-Serine-Threonine Kinases SOX9 Transcription Factor Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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