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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Harvey, Richard Chabab, Samira Blanpain, Cédric Ramialison, Mirana Bondue, Antoine Tännler, Simon Chiapparo, Giuseppe Beck, Benjamin Paulissen, Catherine |
| Description | Author Affiliation: Bondue A ( Université Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, B1070 Bruxelles, Belgium.) |
| Abstract | During embryonic development and embryonic stem cell (ESC) differentiation, the different cell lineages of the mature heart arise from two types of multipotent cardiovascular progenitors (MCPs), the first and second heart fields. A key question is whether these two MCP populations arise from differentiation of a common progenitor. In this paper, we engineered Mesp1–green fluorescent protein (GFP) ESCs to isolate early MCPs during ESC differentiation. Mesp1-GFP cells are strongly enriched for MCPs, presenting the ability to differentiate into multiple cardiovascular lineages from both heart fields in vitro and in vivo. Transcriptional profiling of Mesp1-GFP cells uncovered cell surface markers expressed by MCPs allowing their prospective isolation. Mesp1 is required for MCP specification and the expression of key cardiovascular transcription factors. Isl1 is expressed in a subset of early Mesp1-expressing cells independently of Mesp1 and acts together with Mesp1 to promote cardiovascular differentiation. Our study identifies the early MCPs residing at the top of the cellular hierarchy of cardiovascular lineages during ESC differentiation. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 5 |
| Volume Number | 192 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2011-03-07 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Basic Helix-Loop-Helix Transcription Factors Physiology Cell Differentiation Cell Lineage Embryonic Stem Cells Cytology Myocardium Animals Genetics Gene Expression Profiling Green Fluorescent Proteins Heart Embryology Homeodomain Proteins Metabolism LIM-Homeodomain Proteins Mice Recombinant Fusion Proteins Transcription Factors Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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