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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mao, Kai Zhao, Mantong Klionsky, Daniel J. Wang, Ke Xu, Tao |
| Description | Author Affiliation: Mao K ( Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.) |
| Abstract | Macroautophagy (hereafter referred to simply as autophagy) is a catabolic pathway that mediates the degradation of long-lived proteins and organelles in eukaryotic cells. The regulation of mitochondrial degradation through autophagy plays an essential role in the maintenance and quality control of this organelle. Compared with our understanding of the essential function of mitochondria in many aspects of cellular metabolism such as energy production and of the role of dysfunctional mitochondria in cell death, little is known regarding their degradation and especially how upstream signaling pathways control this process. Here, we report that two mitogen-activated protein kinases (MAPKs), Slt2 and Hog1, are required for mitophagy in Saccharomyces cerevisiae. Slt2 is required for the degradation of both mitochondria and peroxisomes (via pexophagy), whereas Hog1 functions specifically in mitophagy. Slt2 also affects the recruitment of mitochondria to the phagophore assembly site (PAS), a critical step in the packaging of cargo for selective degradation. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 4 |
| Volume Number | 193 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2011-05-16 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | MAP Kinase Signaling System Mitochondria Enzymology Mitochondrial Proteins Metabolism Mitogen-Activated Protein Kinases Saccharomyces Cerevisiae Proteins Saccharomyces Cerevisiae Autophagy Cytoplasm Intracellular Signaling Peptides And Proteins Genetics Membrane Proteins Microscopy, Fluorescence Mitogen-Activated Protein Kinase Kinases Mutation Peroxisomes Phosphorylation Protein Kinases Receptors, Cytoplasmic And Nuclear Recombinant Fusion Proteins Time Factors Research Support, N.I.H., Extramural Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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