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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Won-jing Uryu, Kunihiro Tsou, Meng-fu Bryan Soni, Rajesh Kumar |
| Description | Author Affiliation: Wang WJ ( Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.) |
| Abstract | Centrioles are self-reproducing organelles that form the core structure of centrosomes or microtubule-organizing centers (MTOCs). However, whether duplication and MTOC organization reflect innate activities of centrioles or activities acquired conditionally is unclear. In this paper, we show that newly formed full-length centrioles had no inherent capacity to duplicate or to organize pericentriolar material (PCM) but acquired both after mitosis through a Plk1-dependent modification that occurred in early mitosis. Modified centrioles initiated PCM recruitment in G1 and segregated equally in mitosis through association with spindle poles. Conversely, unmodified centrioles segregated randomly unless passively tethered to modified centrioles. Strikingly, duplication occurred only in centrioles that were both modified and disengaged, whereas unmodified centrioles, engaged or not, were “infertile,” indicating that engagement specifically blocks modified centrioles from reduplication. These two requirements, centriole modification and disengagement, fully exclude unlimited duplication in one cell cycle. We thus uncovered a Plk1-dependent mechanism whereby duplication and segregation are coupled to maintain centriole homeostasis. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 4 |
| Volume Number | 193 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2011-05-16 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Cycle Proteins Metabolism Centrioles Physiology Centrosome Epithelial Cells Mitosis Protein-Serine-Threonine Kinases Proto-Oncogene Proteins Retinal Pigment Epithelium Genetics Cells, Cultured Ultrastructure Fluorescent Antibody Technique HeLa Cells Homeostasis Microscopy, Electron, Transmission Microscopy, Fluorescence Microscopy, Video Proteins RNA Interference Cytology Time Factors Transfection Research Support, N.I.H., Extramural Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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