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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Millard, Tom H. Matsubayashi, Yutaka Coulson-gilmer, Camilla |
| Description | Author Affiliation: Matsubayashi Y ( The Healing Foundation Centre, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, England, UK.); Coulson-Gilmer C ( The Healing Foundation Centre, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, England, UK.); Millard TH ( The Healing Foundation Centre, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, England, UK tom.millard@manchester.ac.uk.) |
| Abstract | The ability to heal wounds efficiently is essential for life. After wounding of an epithelium, the cells bordering the wound form dynamic actin protrusions and/or a contractile actomyosin cable, and these actin structures drive wound closure. Despite their importance in wound healing, the molecular mechanisms that regulate the assembly of these actin structures at wound edges are not well understood. In this paper, using Drosophila melanogaster embryos, we demonstrate that Diaphanous, SCAR, and WASp play distinct but overlapping roles in regulating actin assembly during wound healing. Moreover, we show that endocytosis is essential for wound edge actin assembly and wound closure. We identify adherens junctions (AJs) as a key target of endocytosis during wound healing and propose that endocytic remodeling of AJs is required to form “signaling centers” along the wound edge that control actin assembly. We conclude that coordination of actin assembly, AJ remodeling, and membrane traffic is required for the construction of a motile leading edge during wound healing. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 3 |
| Volume Number | 210 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2015-08-03 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Actins Metabolism Adherens Junctions Endocytosis Physiology Wound Healing Animals Cadherins Genetics Carrier Proteins Clathrin Drosophila Proteins Drosophila Melanogaster Embryology Epithelium Microfilament Proteins Protein Transport Signal Transduction Wiskott-Aldrich Syndrome Protein Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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