Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bothe, Gordana Peacock, Christopher S. Apostolou, Zina Coulson, Richard M. R. Collins, Matt Berriman, Matthew Adlem, Ellen Murphy, Lee Attipoe, Philip Bianchettin, Gabriella Gabel, Claudia Ciarloni, Laura Sisk, Ellen Hilbert, Helmut Horn, David Beck, Alfred Cruz, Angela K. Bason, Nathalie Bruschi, Carlo V. Knights, Andrew Duesterhoeft, Andreas Frasch, Alberto Carlos Huang, Yiting Ivens, Alasdair C. De Gaudenzi, Javier Cronin, Ann Borzym, Katja Fazelina, Gholam Aert, Rita Litvin, Lyudmila Rajandream, Marie-adele Aggarwal, Gautam Fosker, Nigel Davies, Robert M. Larke, Natasha Dobson, Deborah E. Cadag, Eithon Klages, Sven Fraser, Audrey Bauser, Christopher Fuchs, Monika Goble, Arlette Hertz-fowler, Christiane Anupama, Atashi Clayton, Christine Beverley, Stephen M. Kube, Michael Goffeau, André Harris, David Worthey, Elizabeth A. |
| Description | Author Affiliation: Ivens AC ( Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK. alicat@sanger.ac.uk) |
| Abstract | Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36% can be ascribed a putative function. These include genes involved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthesis of complex surface glycoconjugates. The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryp) genomes suggest that the mechanisms regulating RNA polymerase II-directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression. |
| ISSN | 00368075 |
| e-ISSN | 10959203 |
| Journal | Science |
| Issue Number | 5733 |
| Volume Number | 309 |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2005-07-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Genome, Protozoan Leishmania Major Genetics Sequence Analysis, DNA Animals Chromatin Metabolism Gene Expression Regulation Genes, Protozoan Genes, RRNA Glycoconjugates Biosynthesis Chemistry Leishmaniasis, Cutaneous Parasitology Lipid Metabolism Membrane Proteins Molecular Sequence Data Multigene Family Protein Biosynthesis Protein Processing, Post-Translational Protozoan Proteins RNA Processing, Post-Transcriptional RNA Splicing RNA, Protozoan Transcription, Genetic Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|