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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kelderman, Sander Van Buuren, Marit M. Van Rooij, Nienke Donia, Marco Yang, Weiwen Olweus, Johanna Strønen, Erlend Lund-johansen, Fridtjof Böschen, Maxi-lu Schumacher, Ton N. Toebes, Mireille |
| Description | Author Affiliation: Strønen E ( Department of Cancer Immunology, Oslo University Hospital Radiumhospitalet, Oslo, Norway. K. G. Jebsen Centers for Cancer Immunotherapy and for Inflammation Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway.); Toebes M ( Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.); Kelderman S ( Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.); van Buuren MM ( Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.); Yang W ( Department of Cancer Immunology, Oslo University Hospital Radiumhospitalet, Oslo, Norway. K. G. Jebsen Centers for Cancer Immunotherapy and for Inflammation Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway.); van Rooij N ( Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.); Donia M ( Center for Cancer Immune Therapy, Department of Hematology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.); Böschen ML ( Department of Cancer Immunology, Oslo University Hospital Radiumhospitalet, Oslo, Norway. K. G. Jebsen Centers for Cancer Immunotherapy and for Inflammation Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway.); Lund-Johansen F ( K. G. Jebsen Centers for Cancer Immunotherapy and for Inflammation Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway. Department of Immunology and Transfusion Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.); Olweus J ( Department of Cancer Immunology, Oslo University Hospital Radiumhospitalet, Oslo, Norway. K. G. Jebsen Centers for Cancer Immunotherapy and for Inflammation Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway. johanna.olweus@medisin.uio.no t.schumacher@nki.nl.); Schumacher TN ( Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands. johanna.olweus@medisin.uio.no t.schumacher@nki.nl.) |
| Abstract | Accumulating evidence suggests that clinically efficacious cancer immunotherapies are driven by T cell reactivity against DNA mutation-derived neoantigens. However, among the large number of predicted neoantigens, only a minority is recognized by autologous patient T cells, and strategies to broaden neoantigen-specific T cell responses are therefore attractive. We found that naïve T cell repertoires of healthy blood donors provide a source of neoantigen-specific T cells, responding to 11 of 57 predicted human leukocyte antigen (HLA)-A*02:01-binding epitopes from three patients. Many of the T cell reactivities involved epitopes that in vivo were neglected by patient autologous tumor-infiltrating lymphocytes. Finally, T cells redirected with T cell receptors identified from donor-derived T cells efficiently recognized patient-derived melanoma cells harboring the relevant mutations, providing a rationale for the use of such 'outsourced' immune responses in cancer immunotherapy. |
| ISSN | 00368075 |
| Issue Number | 6291 |
| Volume Number | 352 |
| e-ISSN | 10959203 |
| Journal | Science |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2016-06-10 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Antigens, Neoplasm Immunology Epitopes, T-Lymphocyte HLA-A2 Antigen Melanoma Therapy Receptors, Antigen, T-Cell Genetics Blood Donors Cell Line, Tumor Humans Immunotherapy Lymphocytes, Tumor-Infiltrating Mutation Primary Cell Culture RNA, Messenger Transfection Tumor Cells, Cultured Journal Article Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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