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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Awasthi, Sanjay Singhal, Jyotsana Singhal, Sharad S. Yadav, Sushma Drake, Kenneth |
| Description | Author Affiliation: Singhal SS ( Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107-2699, USA.) |
| Abstract | Hsf-1 (heat shock factor-1) is a transcription factor that is known to regulate cellular heat shock response through its binding with the multispecific transporter protein, Ralbp1. Results of present studies demonstrate that Hsf-1 causes specific and saturable inhibition of the transport activity of Ralbp1 and that the combination of Hsf-1 and POB1 causes nearly complete inhibition through specific bindings with Ralbp1. Augmentation of cellular levels of Hsf-1 and POB1 caused dramatic apoptosis in non-small cell lung cancer cell line H358 through Ralbp1 inhibition. These findings indicate a novel model for mutual regulation of Hsf-1 and Ralbp1 through Ralbp1-mediated sequestration of Hsf-1 in the cellular cytoskeleton and Hsf-1-mediated inhibition of the transport activity of membrane-bound Ralbp1. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 28 |
| Volume Number | 283 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2008-07-11 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | ATP-Binding Cassette Transporters Metabolism Apoptosis Carcinoma, Non-Small-Cell Lung DNA-Binding Proteins Drug Resistance, Neoplasm GTPase-Activating Proteins Intracellular Signaling Peptides And Proteins Lung Neoplasms Transcription Factors Genetics Antineoplastic Agents Pharmacology Therapeutic Use Drug Effects Biological Transport Drug Therapy Cytoskeleton Heat-Shock Response K562 Cells Diet Therapy Protein Binding Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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