NDLI: Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants.

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Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants.

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Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bajda, Agnieszka Chojnacki, Tadeusz Szostkiewicz, Izabela Rohmer, Michel Swiezewska, Ewa Olszowska, Olga Wojcik, Jacek Bienkowski, Tomasz Meyer, Odile Skorupinska-tudek, Karolina Grunler, Jacob Zelman-femiak, Monika Poznanski, Jaroslaw Danikiewicz, Witold
Description	Author Affiliation: Skorupinska-Tudek K ( Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland.)
Abstract	Plant isoprenoids are derived from two biosynthetic pathways, the cytoplasmic mevalonate (MVA) and the plastidial methylerythritol phosphate (MEP) pathway. In this study their respective contributions toward formation of dolichols in Coluria geoides hairy root culture were estimated using in vivo labeling with (13)C-labeled glucose as a general precursor. NMR and mass spectrometry showed that both the MVA and MEP pathways were the sources of isopentenyl diphosphate incorporated into polyisoprenoid chains. The involvement of the MEP pathway was found to be substantial at the initiation stage of dolichol chain synthesis, but it was virtually nil at the terminal steps; statistically, 6-8 isoprene units within the dolichol molecule (i.e. 40-50% of the total) were derived from the MEP pathway. These results were further verified by incorporation of [5-(2)H]mevalonate or [5,5-(2)H(2)]deoxyxylulose into dolichols as well as by the observed decreased accumulation of dolichols upon treatment with mevinolin or fosmidomycin, selective inhibitors of either pathway. The presented data indicate that the synthesis of dolichols in C. geoides roots involves a continuous exchange of intermediates between the MVA and MEP pathways. According to our model, oligoprenyl diphosphate chains of a length not exceeding 13 isoprene units are synthesized in plastids from isopentenyl diphosphate derived from both the MEP and MVA pathways, and then are completed in the cytoplasm with several units derived solely from the MVA pathway. This study also illustrates an innovative application of mass spectrometry for qualitative and quantitative evaluation of the contribution of individual metabolic pathways to the biosynthesis of natural products.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	30
Volume Number	283
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2008-07-25
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Dolichol Chemistry Erythritol Analogs & Derivatives Mevalonic Acid Metabolism Plants Sugar Phosphates Alcohols Cytoplasm Glucose Magnetic Resonance Spectroscopy Mass Spectrometry Models, Biological Plant Roots Plastids Probability Spectrometry, Mass, Electrospray Ionization Sterols Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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