NDLI: Identification of LRRc17 as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation.

Please wait, while we are loading the content...

Year: 2017 Volume: 292

Year: 2016 Volume: 291

Year: 2015 Volume: 290

Year: 2014 Volume: 289

Year: 2013 Volume: 288

Year: 2012 Volume: 287

Year: 2011 Volume: 286

Year: 2010 Volume: 285

Year: 2009 Volume: 284

Year: 2009 Volume: 284 Issue: 52

Year: 2009 Volume: 284 Issue: 51

Year: 2009 Volume: 284 Issue: 50

Year: 2009 Volume: 284 Issue: 49

Year: 2009 Volume: 284 Issue: 48

Year: 2009 Volume: 284 Issue: 47

Year: 2009 Volume: 284 Issue: 46

Year: 2009 Volume: 284 Issue: 45

Year: 2009 Volume: 284 Issue: 44

Year: 2009 Volume: 284 Issue: 43

Year: 2009 Volume: 284 Issue: 42

Year: 2009 Volume: 284 Issue: 41

Year: 2009 Volume: 284 Issue: 40

Year: 2009 Volume: 284 Issue: 39

Year: 2009 Volume: 284 Issue: 38

Year: 2009 Volume: 284 Issue: 37

Year: 2009 Volume: 284 Issue: 36

Year: 2009 Volume: 284 Issue: 35

Year: 2009 Volume: 284 Issue: 34

Year: 2009 Volume: 284 Issue: 33

Year: 2009 Volume: 284 Issue: 32

Year: 2009 Volume: 284 Issue: 31

Year: 2009 Volume: 284 Issue: 30

Year: 2009 Volume: 284 Issue: 29

Year: 2009 Volume: 284 Issue: 28

Year: 2009 Volume: 284 Issue: 27

Year: 2009 Volume: 284 Issue: 26

Year: 2009 Volume: 284 Issue: 25

Year: 2009 Volume: 284 Issue: 24

Year: 2009 Volume: 284 Issue: 23

Year: 2009 Volume: 284 Issue: 22

Crystal structure of the N-terminal domain of anaphase-promoting complex subunit 7.

Aquaporin-2 in the '-omics' era.

Placenta-specific Methylation of the Vitamin D 24-Hydroxylase Gene

Effects of differential glycosylation of glycodelins on lymphocyte survival.

Barx2 controls myoblast fusion and promotes MyoD-mediated activation of the smooth muscle alpha-actin gene.

Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction.

Arsenate reductase, mycothiol, and mycoredoxin concert thiol/disulfide exchange.

Role of bound Zn(II) in the CadC Cd(II)/Pb(II)/Zn(II)-responsive repressor.

Overexpression of E-cadherin on melanoma cells inhibits chemokine-promoted invasion involving p190RhoGAP/p120ctn-dependent inactivation of RhoA.

The membrane-binding motif of the chloroplast signal recognition particle receptor (cpFtsY) regulates GTPase activity.

Superoxide-mediated formation of tyrosine hydroperoxides and methionine sulfoxide in peptides through radical addition and intramolecular oxygen transfer.

Inhibition of tumor cell motility by the interferon-inducible GTPase MxA.

Stereospecificity of the siderophore pyochelin outer membrane transporters in fluorescent pseudomonads.

The Structure of an Interdomain Complex That Regulates Talin $Activity^{*S⃞♦}$

Involvement of all-trans-retinal in acute light-induced retinopathy of mice.

Dissection of mechanisms involved in the regulation of Plasmodium falciparum calcium-dependent protein kinase 4.

Light-induced Dissociation of an Antenna Hetero-oligomer Is Needed for Non-photochemical Quenching Induction

Airway Epithelial Inflammation-induced Endoplasmic Reticulum $Ca^{2+}$ Store Expansion Is Mediated by X-box Binding Protein-1

Crystal structure of the GTPase-activating protein-related domain from IQGAP1.

Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin.

Genomic responses from the estrogen-responsive element-dependent signaling pathway mediated by estrogen receptor alpha are required to elicit cellular alterations.

Structure and Orientation of Troponin in the Thin $Filament^{*S⃞}$

Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C.

Methylation-sensitive Regulation of TMS1/ASC by the Ets Factor, GA-binding Protein-α

Biogenic synthesis, purification, and chemical characterization of anti-inflammatory resolvins derived from docosapentaenoic acid (DPAn-6).

In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase.

Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT).

Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex.

The Novel S527F Mutation in the Integrin β3 Chain Induces a High Affinity αIIbβ3 Receptor by Hindering Adoption of the Bent Conformation

Changes in sodium pump expression dictate the effects of ouabain on cell growth.

Abscisic acid activates the murine microglial cell line N9 through the second messenger cyclic ADP-ribose.

Regulation of the Epithelial $Mg^{2+}$ Channel TRPM6 by Estrogen and the Associated Repressor Protein of Estrogen Receptor Activity (REA)

Telomerase-associated Protein 1, HSP90, and Topoisomerase IIα Associate Directly with the BLM Helicase in Immortalized Cells Using ALT and Modulate Its Helicase Activity Using Telomeric DNA Substrates

c-Myc-induced aberrant DNA synthesis and activation of DNA damage response in p300 knockdown cells.

p90 Ribosomal S6 Kinase and p70 Ribosomal S6 Kinase Link Phosphorylation of the Eukaryotic Chaperonin Containing TCP-1 to Growth Factor, Insulin, and Nutrient Signaling

Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells.

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by $Mitochondria^{*S⃞}$

G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor.

Bypassing Kinase Activity of the Tomato Pto Resistance Protein with Small Molecule Ligands

The water channel aquaporin 1 is a novel molecular target of polychlorinated biphenyls for in utero anomalies.

Ionizing radiation induces ATM-independent degradation of p21Cip1 in transformed cells.

Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta.

Structure and Functional Analysis of a $Ca^{2+}$ Sensor Mutant of the $Na^{+}/Ca^{2+}$ Exchanger

Analysis of a critical interaction within the archaeal box C/D small ribonucleoprotein complex.

Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers.

Identification of LRRc17 as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation.

Soluble Adenylyl Cyclase Controls Mitochondria-dependent Apoptosis in Coronary Endothelial Cells

Identification of a Novel $Zn^{2+}-binding$ Domain in the Autosomal Recessive Juvenile Parkinson-related E3 Ligase Parkin

Structural evidence of substrate specificity in mammalian peroxidases: structure of the thiocyanate complex with lactoperoxidase and its interactions at 2.4 A resolution.

Cooperative Folding and Ligand-binding Properties of LRP6 β-Propeller Domains

Self-subunit swapping chaperone needed for the maturation of multimeric metalloenzyme nitrile hydratase by a subunit exchange mechanism also carries out the oxidation of the metal ligand cysteine residues and insertion of cobalt.

Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity Is Associated with Phosphorylation of Raptor by mTOR

Effect of Transient and Permanent Permeability Transition Pore Opening on NAD(P)H Localization in Intact Cells

Lot1 Is a Key Element of the Pituitary Adenylate Cyclase-activating Polypeptide (PACAP)/Cyclic AMP Pathway That Negatively Regulates Neuronal Precursor Proliferation

Polymeric osteopontin employs integrin alpha9beta1 as a receptor and attracts neutrophils by presenting a de novo binding site.

Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome.

Topogenesis of mammalian Oxa1, a component of the mitochondrial inner membrane protein export machinery.

Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle.

Identification and manipulation of the caprazamycin gene cluster lead to new simplified liponucleoside antibiotics and give insights into the biosynthetic pathway.

Essential role of Hrs in endocytic recycling of full-length TrkB receptor but not its isoform TrkB.T1.

A methyltransferase-independent function for Rmt3 in ribosomal subunit homeostasis.

Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways.

Regulation of intracellular cholesterol distribution by Na/K-ATPase.

Glutathione participates in the regulation of mitophagy in yeast.

Interrelationship between liver X receptor alpha, sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma, and small heterodimer partner in the transcriptional regulation of glucokinase gene expression in liver.

Phospholipase D-mediated Activation of IQGAP1 through Rac1 Regulates Hyperoxia-induced $p47^{phox}$ Translocation and Reactive Oxygen Species Generation in Lung Endothelial Cells

Year: 2009 Volume: 284 Issue: 21

Year: 2009 Volume: 284 Issue: 20

Year: 2009 Volume: 284 Issue: 19

Year: 2009 Volume: 284 Issue: 18

Year: 2009 Volume: 284 Issue: 17

Year: 2009 Volume: 284 Issue: 16

Year: 2009 Volume: 284 Issue: 15

Year: 2009 Volume: 284 Issue: 14

Year: 2009 Volume: 284 Issue: 13

Year: 2009 Volume: 284 Issue: 12

Year: 2009 Volume: 284 Issue: 11

Year: 2009 Volume: 284 Issue: 10

Year: 2009 Volume: 284 Issue: 9

Year: 2009 Volume: 284 Issue: 8

Year: 2009 Volume: 284 Issue: 7

Year: 2009 Volume: 284 Issue: 6

Year: 2009 Volume: 284 Issue: 5

Year: 2009 Volume: 284 Issue: 4

Year: 2009 Volume: 284 Issue: 3

Year: 2009 Volume: 284 Issue: 2

Year: 2009 Volume: 284 Issue: 1

Year: 2008 Volume: 283

Year: 2007 Volume: 282

Year: 2006 Volume: 281

Year: 2005 Volume: 280

Year: 2004 Volume: 279

Year: 2003 Volume: 278

Year: 2002 Volume: 277

Year: 2001 Volume: 276

Year: 2000 Volume: 275

Year: 1999 Volume: 274

Year: 1998 Volume: 273

Year: 1997 Volume: 272

Year: 1996 Volume: 271

Year: 1995 Volume: 270

Year: 1994 Volume: 269

Year: 1993 Volume: 268

Year: 1992 Volume: 267

Year: 1991 Volume: 266

Year: 1990 Volume: 265

Year: 1989 Volume: 264

Year: 1988 Volume: 263

Year: 1987 Volume: 262

Year: 1986 Volume: 261

Year: 1984 Volume: 259

Year: 1982 Volume: 257

Year: 1981 Volume: 256

Year: 1975 Volume: 250

Identification of LRRc17 as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lee, Seoung Hoon So, Hong-seob Kim, Taesoo Lee, Junwon Kim, Nacksung Kim, Kabsun Choi, Yongwon
Description	Author Affiliation: Kim T ( Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.)
Abstract	Osteoblasts are the primary cells responsible for bone formation. They also support osteoclast formation from bone marrow precursors in response to osteotropic factors by inducing receptor activator of NF-kappaB ligand (RANKL) expression and down-regulating osteoprotegerin (OPG) production. In addition to the RANKL-RANK-OPG signaling axis, other factors produced by osteoblasts/stromal cells are involved in osteoclastogenesis. Here, we describe the identification and characterization of leucine-rich repeat-containing 17 (LRRc17), a member of the LRR superfamily that acts as a negative regulator of RANKL-induced osteoclast differentiation. Osteoblasts showed high levels of LRRc17 expression, which was down-regulated in response to the pro-osteoclastogenic factor 1,25-dihydroxyvitamin D(3). Recombinant LRRc17 protein inhibited RANKL-induced osteoclast differentiation from bone marrow precursors, whereas it did not affect the differentiation or activation of macrophages and dendritic cells. These results suggest that among the cell types derived from common myeloid precursors, LRRc17 specifically regulates osteoclasts. Further analysis revealed that LRRc17 attenuated RANKL-induced expression of NFATc1 by blocking phospholipase C-gamma signaling, which, in turn, inhibited RANKL-mediated osteoclast differentiation. Taken together, our results demonstrated a novel inhibitory activity of LRRc17 in RANKL-induced osteoclastogenesis.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	22
Volume Number	284
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2009-05-29
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Differentiation Osteoclasts Cytology Metabolism Proteins RANK Ligand Animals Calcitriol Pharmacology Drug Effects Dendritic Cells Down-Regulation Macrophages Mice Mice, Inbred C57BL NFATC Transcription Factors Osteoblasts Phagocytosis Phospholipase C Gamma Genetics RNA, Messenger Signal Transduction Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in