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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Taulet, Nicolas Bodin, Stéphane Gauthier-rouvière, Cécile Charrasse, Sophie Favard, Cyril Comunale, Franck |
| Description | Author Affiliation: Taulet N ( Centre de Recherche de Biochimie Macromoléculaire, Universités Montpellier 2 et 1, CNRS, Uníté Mixte de Recherche 5237, Institut Fédératif de Recherche 122, 1919 Route de Mende, 34293 Montpellier, France.) |
| Abstract | p120 catenin is a major regulator of cadherin stability at cell-cell contacts and a modulator of Rho GTPase activities. In C2C12 myoblasts, N-cadherin is stabilized at cell contacts through its association with cholesterol-rich membrane domains or lipid rafts (LR) and acts as an adhesion-activated receptor that activates RhoA, an event required for myogenesis induction. Here, we report that association of p120 catenin with N-cadherin at cell contacts occurs specifically in LR. We demonstrate that interaction of p120 catenin with N-cadherin is required for N-cadherin association with LR and for its stabilization at cell contacts. LR disruption inhibits myogenesis induction and N-cadherin-dependent RhoA activation as does the perturbation of the N-cadherin-p120 catenin complex after p120 catenin knockdown. Finally, we observe an N-cadherin-dependent accumulation of RhoA at phosphatidylinositol 4,5-bisphosphate-enriched cell contacts which is lost after LR disruption. Thus, a functional N-cadherin-catenin complex occurs in cholesterol-rich membrane microdomains which allows the recruitment of RhoA and the regulation of its activity during myogenesis induction. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 34 |
| Volume Number | 284 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2009-08-21 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cadherins Metabolism Cell Adhesion Molecules Cell Membrane Chemistry Cholesterol Muscle Development Physiology Phosphoproteins RhoA GTP-Binding Protein Animals Catenins Genetics Cell Line Fluorescence Recovery After Photobleaching Immunohistochemistry Immunoprecipitation Intercellular Junctions Mice Protein Binding Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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