NDLI: Repression of sulfate assimilation is an adaptive response of yeast to the oxidative stress of zinc deficiency.

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Repression of sulfate assimilation is an adaptive response of yeast to the oxidative stress of zinc deficiency.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Winge, Dennis R. Roje, Sanja Sandoval, Francisco J. Bird, Amanda J. Wu, Chang-yi Eide, David J.
Description	Author Affiliation: Wu CY ( Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA.)
Abstract	The Zap1 transcription factor is a central player in the response of yeast to changes in zinc status. Previous studies identified over 80 genes activated by Zap1 in zinc-limited cells. In this report, we identified 36 genes repressed in a zinc- and Zap1-responsive manner. As a result, we have identified a new mechanism of Zap1-mediated gene repression whereby transcription of the MET3, MET14, and MET16 genes is repressed in zinc-limited cells. These genes encode the first three enzymes of the sulfate assimilation pathway. We found that MET30, encoding a component of the SCF(Met30) ubiquitin ligase, is a direct Zap1 target gene. MET30 expression is increased in zinc-limited cells, and this leads to degradation of Met4, a transcription factor responsible for MET3, MET14, and MET16 expression. Thus, Zap1 is responsible for a decrease in sulfate assimilation in zinc-limited cells. We further show that cells that are unable to down-regulate sulfate assimilation under zinc deficiency experience increased oxidative stress. This increased oxidative stress is associated with an increase in the NADP(+)/NADPH ratio and may result from a decrease in NADPH-dependent antioxidant activities. These studies have led to new insights into how cells adapt to nutrient-limiting growth conditions.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	40
Volume Number	284
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2009-10-02
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adaptation, Physiological Oxidative Stress Saccharomyces Cerevisiae Metabolism Sulfates Zinc Deficiency Basic-Leucine Zipper Transcription Factors Down-Regulation F-Box Proteins Genetics Gene Expression Regulation, Fungal NADP Proteasome Endopeptidase Complex Physiology Saccharomyces Cerevisiae Proteins Transcription Factors Transcription, Genetic Transcriptional Activation Ubiquitin Ubiquitin-Protein Ligase Complexes Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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