NDLI: Tissue-specific role of the Na,K-ATPase 2 isozyme in skeletal muscle.

Please wait, while we are loading the content...

Year: 2017 Volume: 292

Year: 2016 Volume: 291

Year: 2015 Volume: 290

Year: 2014 Volume: 289

Year: 2013 Volume: 288

Year: 2013 Volume: 288 Issue: 52

Year: 2013 Volume: 288 Issue: 51

Year: 2013 Volume: 288 Issue: 50

Year: 2013 Volume: 288 Issue: 49

Year: 2013 Volume: 288 Issue: 48

Year: 2013 Volume: 288 Issue: 47

Year: 2013 Volume: 288 Issue: 46

Year: 2013 Volume: 288 Issue: 45

Year: 2013 Volume: 288 Issue: 44

Year: 2013 Volume: 288 Issue: 43

Year: 2013 Volume: 288 Issue: 42

Year: 2013 Volume: 288 Issue: 41

Year: 2013 Volume: 288 Issue: 40

Year: 2013 Volume: 288 Issue: 39

Year: 2013 Volume: 288 Issue: 38

Year: 2013 Volume: 288 Issue: 37

Year: 2013 Volume: 288 Issue: 36

Year: 2013 Volume: 288 Issue: 35

Year: 2013 Volume: 288 Issue: 34

Year: 2013 Volume: 288 Issue: 33

Year: 2013 Volume: 288 Issue: 32

Year: 2013 Volume: 288 Issue: 31

Year: 2013 Volume: 288 Issue: 30

Year: 2013 Volume: 288 Issue: 29

Year: 2013 Volume: 288 Issue: 28

Year: 2013 Volume: 288 Issue: 27

Year: 2013 Volume: 288 Issue: 26

Year: 2013 Volume: 288 Issue: 25

Year: 2013 Volume: 288 Issue: 24

Year: 2013 Volume: 288 Issue: 23

Year: 2013 Volume: 288 Issue: 22

Year: 2013 Volume: 288 Issue: 21

Year: 2013 Volume: 288 Issue: 20

Year: 2013 Volume: 288 Issue: 19

Year: 2013 Volume: 288 Issue: 18

Year: 2013 Volume: 288 Issue: 17

Year: 2013 Volume: 288 Issue: 16

Year: 2013 Volume: 288 Issue: 15

Year: 2013 Volume: 288 Issue: 14

Year: 2013 Volume: 288 Issue: 13

Year: 2013 Volume: 288 Issue: 12

Year: 2013 Volume: 288 Issue: 11

Year: 2013 Volume: 288 Issue: 10

Year: 2013 Volume: 288 Issue: 9

Year: 2013 Volume: 288 Issue: 8

Year: 2013 Volume: 288 Issue: 7

Year: 2013 Volume: 288 Issue: 6

Year: 2013 Volume: 288 Issue: 5

Year: 2013 Volume: 288 Issue: 4

Year: 2013 Volume: 288 Issue: 3

Year: 2013 Volume: 288 Issue: 2

Liver retinol transporter and receptor for serum retinol-binding protein (RBP4).

Staphylococcus aureus uses a novel multidomain receptor to break apart human hemoglobin and steal its heme.

Chaperone proteins select and maintain [PIN+] prion conformations in Saccharomyces cerevisiae.

High mobility group Box 1 inhibits human pulmonary artery endothelial cell migration via a Toll-like receptor 4- and interferon response factor 3-dependent mechanism(s).

Runt-related transcription factor 1 (RUNX1) stimulates tumor suppressor p53 protein in response to DNA damage through complex formation and acetylation.

Altering hydrophobic sequence lengths shows that hydrophobic mismatch controls affinity for ordered lipid domains (rafts) in the multitransmembrane strand protein perfringolysin O.

Identification of the components of a glycolytic enzyme metabolon on the human red blood cell membrane.

Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction.

Interplay between α-, β-, and γ-Secretases Determines Biphasic Amyloid-β Protein Level in the Presence of a γ-Secretase $Inhibitor^{}$

Characterization of a small molecule inhibitor of plasminogen activator inhibitor type 1 that accelerates the transition into the latent conformation.

Inhibition of glycogen synthase kinase-3 ameliorates ß-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies.

The Src substrate SKAP2 regulates actin assembly by interacting with WAVE2 and cortactin proteins.

Structural insight into coordinated recognition of trimethylated histone H3 lysine 9 (H3K9me3) by the plant homeodomain (PHD) and tandem tudor domain (TTD) of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) protein.

Biphasic regulation of myosin light chain phosphorylation by p21-activated kinase modulates intestinal smooth muscle contractility.

The ß sliding clamp closes around DNA prior to release by the Escherichia coli clamp loader Î³ complex.

Molecular interaction studies of HIV-1 matrix protein p17 and heparin: identification of the heparin-binding motif of p17 as a target for the development of multitarget antagonists.

Interaction between the elastin peptide VGVAPG and human elastin binding protein.

Functional expression of SCL/TAL1 interrupting locus (Stil) protects retinal dopaminergic cells from neurotoxin-induced degeneration.

Mode of cell death induction by pharmacological vacuolar H+-ATPase (V-ATPase) inhibition.

Novel association between vasoactive intestinal peptide and CRTH2 receptor in recruiting eosinophils: a possible biochemical mechanism for allergic eosinophilic inflammation of the airways.

The Escherichia coli toxin MqsR destabilizes the transcriptional repression complex formed between the antitoxin MqsA and the mqsRA operon promoter.

The Neuroendocrine Protein 7B2 Suppresses the Aggregation of Neurodegenerative Disease-related $Proteins^{*}$

The C-terminal peptide of chondroadherin modulates cellular activity by selectively binding to heparan sulfate chains.

Choline Supplementary promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action.

Molecular Mechanism by Which Surface Antigen HP0197 Mediates Host Cell Attachment in the Pathogenic Bacteria Streptococcus suis

XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation.

Mammalian and malaria parasite cyclase-associated proteins catalyze nucleotide exchange on G-actin through a conserved mechanism.

An inhibitory antibody against dipeptidyl peptidase IV improves glucose tolerance in vivo.

Blocking c-Jun N-terminal kinase (JNK) translocation to the mitochondria prevents 6-hydroxydopamine-induced toxicity in vitro and in vivo.

ELMO recruits actin cross-linking family 7 (ACF7) at the cell membrane for microtubule capture and stabilization of cellular protrusions.

In vivo activation of azipropofol prolongs anesthesia and reveals synaptic targets.

Identification of a His-Asp-Cys catalytic triad essential for function of the Rho inactivation domain (RID) of Vibrio cholerae MARTX toxin.

ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2).

Pyroglutamate and O-linked glycan determine functional production of anti-IL17A and anti-IL22 peptide-antibody bispecific genetic fusions.

Characterization of a novel -conotoxin from conus textile that selectively targets 6/ 3ß2ß3 nicotinic acetylcholine receptors.

Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways.

Rab7 mutants associated with Charcot-Marie-Tooth disease cause delayed growth factor receptor transport and altered endosomal and nuclear signaling.

New insights into the assembly of bacterial secretins: structural studies of the periplasmic domain of XcpQ from Pseudomonas aeruginosa.

Functional analysis of Rad14p, a DNA damage recognition factor in nucleotide excision repair, in regulation of transcription in vivo.

Cysteine Scanning Mutagenesis of Transmembrane Helix 3 of a Brain Glutamate Transporter Reveals Two Conformationally Sensitive Positions

Asymmetric regulation of bipolar single-stranded DNA translocation by the two motors within Escherichia coli RecBCD helicase.

Transport of the GlcNAc-1-phosphotransferase /ß-subunit precursor protein to the Golgi apparatus requires a combinatorial sorting motif.

Tissue-specific role of the Na,K-ATPase 2 isozyme in skeletal muscle.

Structural insights into the inactive subunit of the apicoplast-localized caseinolytic protease complex of Plasmodium falciparum.

Anaphase-promoting complex/cyclosome-mediated proteolysis of Ams2 in the G1 phase ensures the coupling of histone gene expression to DNA replication in fission yeast.

Molecular mechanisms underlying cardiac protein phosphatase 2A regulation in heart.

Mitochondrial reactive oxygen species regulate transforming growth factor-ß signaling.

Modeling a ryanodine receptor N-terminal domain connecting the central vestibule and the corner clamp region.

Pak2 kinase restrains mast cell FcÎµRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity.

The collagen-binding integrin 2ß1 is a novel interaction partner of the Trimeresurus flavoviridis venom protein flavocetin-A.

ADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cells.

The developing chicken yolk sac acquires nutrient transport competence by an orchestrated differentiation process of its endodermal epithelial cells.

Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling following denervation.

Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis.

Effect of mutations of arginine 94 on proton pumping, electron transfer, and superoxide anion generation in cytochrome b of the bc1 complex from Rhodobacter sphaeroides.

Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone.

Zinc-dependent regulation of the Adh1 antisense transcript in fission yeast.

Visualization of Structural Changes Accompanying Activation of N-Methyl-d-aspartate (NMDA) Receptors Using Fast-scan Atomic Force Microscopy $Imaging^{*}$

The chemical synthesis of DNA/RNA: our gift to science.

The dual-specificity phosphatase DUSP14 negatively regulates tumor necrosis factor- and interleukin-1-induced nuclear factor-κB activation by dephosphorylating the protein kinase TAK1.

Year: 2013 Volume: 288 Issue: 1

Year: 2012 Volume: 287

Year: 2011 Volume: 286

Year: 2010 Volume: 285

Year: 2009 Volume: 284

Year: 2008 Volume: 283

Year: 2007 Volume: 282

Year: 2006 Volume: 281

Year: 2005 Volume: 280

Year: 2004 Volume: 279

Year: 2003 Volume: 278

Year: 2002 Volume: 277

Year: 2001 Volume: 276

Year: 2000 Volume: 275

Year: 1999 Volume: 274

Year: 1998 Volume: 273

Year: 1997 Volume: 272

Year: 1996 Volume: 271

Year: 1995 Volume: 270

Year: 1994 Volume: 269

Year: 1993 Volume: 268

Year: 1992 Volume: 267

Year: 1991 Volume: 266

Year: 1990 Volume: 265

Year: 1989 Volume: 264

Year: 1988 Volume: 263

Year: 1987 Volume: 262

Year: 1986 Volume: 261

Year: 1984 Volume: 259

Year: 1982 Volume: 257

Year: 1981 Volume: 256

Year: 1975 Volume: 250

Tissue-specific role of the Na,K-ATPase 2 isozyme in skeletal muscle.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Goldhamer, David J. Heiny, Judith A. Rindler, Tara N. Oshiro, Naomi Lingrel, Jerry B. Radzyukevich, Tatiana L. Neumann, Jonathon C.
Description	Author Affiliation: Radzyukevich TL ( Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576 USA.)
Abstract	The Na,K-ATPase 2 isozyme is the major Na,K-ATPase of mammalian skeletal muscle. This distribution is unique compared with most other cells, which express mainly the Na,K-ATPase 1 isoform, but its functional significance is not known. We developed a gene-targeted mouse (sk 2(-/-)) in which the 2 gene (Atp1a2) is knocked out in the skeletal muscles, and examined the consequences for exercise performance, membrane potentials, contractility, and muscle fatigue. Targeted knockout was confirmed by genotyping, Western blot, and immunohistochemistry. Skeletal muscle cells of sk 2(-/-) mice completely lack 2 protein and have no 2 in the transverse tubules, where its expression is normally enhanced. The 1 isoform, which is normally enhanced on the outer sarcolemma, is up-regulated 2.5-fold without change in subcellular targeting. sk 2(-/-) mice are apparently normal under basal conditions but show significantly reduced exercise capacity when challenged to run. Their skeletal muscles produce less force, are unable to increase force to match demand, and show significantly increased susceptibility to fatigue. The impairments affect both fast and slow muscle types. The subcellular targeting of 2 to the transverse tubules is important for this role. Increasing Na,K-ATPase 1 content cannot fully compensate for the loss of 2. The increased fatigability of sk 2(-/-) muscles is reproduced in control extensor digitorum longus muscles by selectively inhibiting 2 enzyme activity with ouabain. These results demonstrate that the Na,K-ATPase 2 isoform performs an acute, isoform-specific role in skeletal muscle. Its activity is regulated by muscle use and enables working muscles to maintain contraction and resist fatigue.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	2
Volume Number	288
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2013-01-11
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Isoenzymes Metabolism Muscle, Skeletal Enzymology Sodium-Potassium-Exchanging ATPase Animals Blotting, Western DNA Primers Immunohistochemistry Mice Mice, Knockout Muscle Contraction Physiology Polymerase Chain Reaction Research Support, N.I.H., Extramural Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in