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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rawnsley, David R. He, Jie Basu, Arindam Pack, Michael Gasa, Rosa Kahn, Mark L. Mericko-ishizuka, Patricia Lee, John S. Lynn, Francis C. Kumar, Vinayak Lu, Minmin Liu, Xi Xiao, Jiping |
| Description | Author Affiliation: Rawnsley DR ( Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.) |
| Abstract | GATA and Friend of GATA (FOG) form a transcriptional complex that plays a key role in cardiovascular development in both fish and mammals. In the present study we demonstrate that the basic helix-loop-helix transcription factor Atonal homolog 8 (Atoh8) is required for development of the heart in fish but not in mice. Genetic studies reveal that Atoh8 interacts specifically with Gata4 and Fog1 during development of the heart and swim bladder in the fish. Biochemical studies reveal that ATOH8, GATA4, and FOG2 associate in a single complex in vitro. In contrast to fish, ATOH8-deficient mice exhibit normal cardiac development and loss of ATOH8 does not alter cardiac development in Gata4(+/-) mice. This species difference in the role of ATOH8 is explained in part by LacZ and GFP reporter alleles that reveal restriction of Atoh8 expression to atrial but not ventricular myocardium in the mouse. Our findings identify ATOH8 as a novel regulator of GATA-FOG function that is required for cardiac development in the fish but not the mouse. Whether ATOH8 modulates GATA-FOG function at other sites or in more subtle ways in mammals is not yet known. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 34 |
| Volume Number | 288 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2013-08-23 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Basic Helix-Loop-Helix Transcription Factors Metabolism DNA-Binding Proteins GATA Transcription Factors GATA4 Transcription Factor Organogenesis Physiology Transcription Factors Zebrafish Proteins Zebrafish Embryology Air Sacs Animals Genetics Heart Atria Heart Ventricles Mice Mice, Transgenic Multiprotein Complexes Myocardium Organ Specificity Research Support, N.I.H., Extramural Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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