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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chi, Fangtao Jin, Daqing Zhong, Tao P. Jiang, Dandan Liu, Huan Zhao, Yiqiang Dai, Xiaoming Guan, Kun-liang Guo, Xiaocan Zhao, Bin She, Peilu Feng, Ying |
| Description | Author Affiliation: Dai X ( From the Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou, Zhejiang 310058, China.) |
| Abstract | The Hippo tumor suppressor pathway plays important roles in organ size control through Lats1/2 mediated phosphorylation of the YAP/TAZ transcription co-activators. However, YAP/TAZ independent functions of the Hippo pathway are largely unknown. Here we report a novel role of the Hippo pathway in angiogenesis. Angiomotin p130 isoform (AMOTp130) is phosphorylated on a conserved HXRXXS motif by Lats1/2 downstream of GPCR signaling. Phosphorylation disrupts AMOT interaction with F-actin and correlates with reduced F-actin stress fibers and focal adhesions. Furthermore, phosphorylation of AMOT by Lats1/2 inhibits endothelial cell migration in vitro and angiogenesis in zebrafish embryos in vivo. Thus AMOT is a direct substrate of Lats1/2 mediating functions of the Hippo pathway in endothelial cell migration and angiogenesis. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 47 |
| Volume Number | 288 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2013-11-22 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Actins Metabolism Cell Movement Physiology Embryo, Nonmammalian Intercellular Signaling Peptides And Proteins Membrane Proteins Neovascularization, Physiologic Protein-Serine-Threonine Kinases Tumor Suppressor Proteins Genetics Amino Acid Motifs Animals COS Cells Cercopithecus Aethiops Cytology Focal Adhesions HEK293 Cells Human Umbilical Vein Endothelial Cells Zebrafish Zebrafish Proteins Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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