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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Setten, Ryan Schones, Dustin E. Chen, Yin Leung, Amy Lusis, Aldons J. Parks, Brian W. Du, Juan Brown, Kevin Trac, Candi Natarajan, Rama |
| Description | Author Affiliation: Leung A ( From the Departments of Diabetes and.); Parks BW ( the Department of Medicine, UCLA, Los Angeles, California 90095.); Du J ( Cancer Biology, Beckman Research Institute and the Irell & Manella Graduate School of Biological Sciences, City of Hope, Duarte, California 91010 and.); Trac C ( Cancer Biology, Beckman Research Institute and.); Setten R ( the Irell & Manella Graduate School of Biological Sciences, City of Hope, Duarte, California 91010 and.); Chen Y ( the Irell & Manella Graduate School of Biological Sciences, City of Hope, Duarte, California 91010 and.); Brown K ( Cancer Biology, Beckman Research Institute and.); Lusis AJ ( the Department of Medicine, UCLA, Los Angeles, California 90095.); Natarajan R ( From the Departments of Diabetes and the Irell & Manella Graduate School of Biological Sciences, City of Hope, Duarte, California 91010 and rnatarajan@coh.org.); Schones DE ( Cancer Biology, Beckman Research Institute and the Irell & Manella Graduate School of Biological Sciences, City of Hope, Duarte, California 91010 and dschones@coh.org.) |
| Abstract | Metabolic diseases result from multiple genetic and environmental factors. We report here that one manner in which environmental factors can contribute to metabolic disease progression is through modification to chromatin. We demonstrate that high fat diet leads to chromatin remodeling in the livers of C57BL/6J mice, as compared with mice fed a control diet, and that these chromatin changes are associated with changes in gene expression. We further show that the regions of greatest variation in chromatin accessibility are targeted by liver transcription factors, including HNF4 , CCAAT/enhancer-binding protein (CEBP/ ), and FOXA1. Repeating the chromatin and gene expression profiling in another mouse strain, DBA/2J, revealed that the regions of greatest chromatin change are largely strain-specific and that integration of chromatin, gene expression, and genetic data can be used to characterize regulatory regions. Our data indicate dramatic changes in the epigenome due to diet and demonstrate strain-specific dynamics in chromatin remodeling. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 34 |
| Volume Number | 289 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2014-08-22 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Chromatin Assembly And Disassembly Chromatin Metabolism Diet, High-Fat Liver Animals Chromatin Immunoprecipitation DNA Primers Mice Mice, Inbred C57BL Mice, Inbred DBA Quantitative Trait Loci Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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