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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ko, Eunbi Park, Kkot-nara Kim, Minsun Bae, Il-hong Lee, Tae Ryong Sung, Young Kwan Shin, Dong Wook Choi, Hyun Bae, Yun Soo Kim, Borim |
| Description | Author Affiliation: Ko E ( From the Department of Life Science and GT5 program, Ewha Womans University.); Choi H ( Bioscience Research Institute, Amorepacific Corporation R&D Center, Yongin-si, Gyeonggi-do, 446-729 and.); Kim B ( From the Department of Life Science and GT5 program, Ewha Womans University.); Kim M ( From the Department of Life Science and GT5 program, Ewha Womans University.); Park KN ( From the Department of Life Science and GT5 program, Ewha Womans University.); Bae IH ( Bioscience Research Institute, Amorepacific Corporation R&D Center, Yongin-si, Gyeonggi-do, 446-729 and.); Sung YK ( the Department of Immunology, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea.); Lee TR ( Bioscience Research Institute, Amorepacific Corporation R&D Center, Yongin-si, Gyeonggi-do, 446-729 and.); Shin DW ( Bioscience Research Institute, Amorepacific Corporation R&D Center, Yongin-si, Gyeonggi-do, 446-729 and biopang@amorepacific.com.); Bae YS ( From the Department of Life Science and GT5 program, Ewha Womans University, baeys@ewha.ac.kr.) |
| Abstract | Testosterone is an endocrine hormone with functions in reproductive organs, anabolic events, and skin homeostasis. We report here that GPRC6A serves as a sensor and mediator of the rapid action of testosterone in epidermal keratinocytes. The silencing of GPRC6A inhibited testosterone-induced intracellular calcium ([Ca(2+)]i) mobilization and H2O2 generation. These results indicated that a testosterone-GPRC6A complex is required for activation of Gq protein, IP3 generation, and [Ca(2+)]i mobilization, leading to Duox1 activation. H2O2 generation by testosterone stimulated the apoptosis of keratinocytes through the activation of caspase-3. The application of testosterone into three-dimensional skin equivalents increased the apoptosis of keratinocytes between the granular and stratified corneum layers. These results support an understanding of the molecular mechanism of testosterone-dependent apoptosis in which testosterone stimulates H2O2 generation through the activation of Duox1. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 42 |
| Volume Number | 289 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2014-10-17 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Gene Expression Regulation, Enzymologic Keratinocytes Metabolism NADPH Oxidase Receptors, G-Protein-Coupled Skin Testosterone Chemistry Apoptosis Calcium Caspase 3 Cell Line Gene Expression Profiling Hydrogen Peroxide Membrane Potential, Mitochondrial Oxidation-Reduction Signal Transduction Cytology Drug Effects Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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