NDLI: Genome-wide approaches reveal functional vascular endothelial growth factor (VEGF)-inducible nuclear factor of activated T cells (NFAT) c1 binding to angiogenesis-related genes in the endothelium.

Please wait, while we are loading the content...

Year: 2017 Volume: 292

Year: 2016 Volume: 291

Year: 2015 Volume: 290

Year: 2014 Volume: 289

Year: 2014 Volume: 289 Issue: 52

Year: 2014 Volume: 289 Issue: 51

Year: 2014 Volume: 289 Issue: 50

Year: 2014 Volume: 289 Issue: 49

Year: 2014 Volume: 289 Issue: 48

Year: 2014 Volume: 289 Issue: 47

Year: 2014 Volume: 289 Issue: 46

Year: 2014 Volume: 289 Issue: 45

Year: 2014 Volume: 289 Issue: 44

Year: 2014 Volume: 289 Issue: 43

Year: 2014 Volume: 289 Issue: 42

Irreversible heavy chain transfer to chondroitin.

Biochemical characterization of the topoisomerase domain of Methanopyrus kandleri topoisomerase V.

A Reciprocal Shift in Transient Receptor Potential Channel 1 (TRPC1) and Stromal Interaction Molecule 2 (STIM2) Contributes to $Ca^{2+}$ Remodeling and Cancer Hallmarks in Colorectal Carcinoma Cells

Single expressed glycine receptor domains reconstitute functional ion channels without subunit-specific desensitization behavior.

Quantitative Lys-Ïµ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.

Genome-wide approaches reveal functional vascular endothelial growth factor (VEGF)-inducible nuclear factor of activated T cells (NFAT) c1 binding to angiogenesis-related genes in the endothelium.

Prion-like nanofibrils of small molecules (PriSM) selectively inhibit cancer cells by impeding cytoskeleton dynamics.

Nuclear Matrix Protein SMAR1 Represses c-Fos-mediated HPV18 E6 Transcription through Alteration of Chromatin Histone Deacetylation

First demonstration of transmissible spongiform encephalopathy-associated prion protein (PrPTSE) in extracellular vesicles from plasma of mice infected with mouse-adapted variant Creutzfeldt-Jakob disease by in vitro amplification.

Dysbindin-1C is required for the survival of hilar mossy cells and the maturation of adult newborn neurons in dentate gyrus.

Escherichia coli D-malate dehydrogenase, a generalist enzyme active in the leucine biosynthesis pathway.

Endocytosis of secreted carboxyl ester lipase in a syndrome of diabetes and pancreatic exocrine dysfunction.

Homologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplication.

Interactions with actin monomers, actin filaments, and Arp2/3 complex define the roles of WASP family proteins and cortactin in coordinately regulating branched actin networks.

Leigh Syndrome in Drosophila melanogaster

Mammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folates.

The microtubule-associated protein EB1 links AIM2 inflammasomes with autophagy-dependent secretion.

Testosterone Stimulates Duox1 Activity through GPRC6A in Skin Keratinocytes

Short Forms of Ste20-related Proline/Alanine-rich Kinase (SPAK) in the Kidney Are Created by Aspartyl Aminopeptidase (Dnpep)-mediated Proteolytic Cleavage

Hydrogen Sulfide Alleviates Diabetic Nephropathy in a Streptozotocin-induced Diabetic Rat Model

RecO protein initiates DNA recombination and strand annealing through two alternative DNA binding mechanisms.

HIV-1 protein Nef inhibits activity of ATP-binding cassette transporter A1 by targeting endoplasmic reticulum chaperone calnexin.

Mechanisms of mitochondrial holocytochrome c synthase and the key roles played by cysteines and histidine of the heme attachment site, Cys-XX-Cys-His.

In vitro amyloidogenic peptides of galectin-7: possible mechanism of amyloidogenesis of primary localized cutaneous amyloidosis.

Glutamine synthetase stability and subcellular distribution in astrocytes are regulated by Î³-aminobutyric type B receptors.

Mechanism of the 6-hydroxy-3-succinoyl-pyridine 3-monooxygenase flavoprotein from Pseudomonas putida S16.

The solution structure, binding properties, and dynamics of the bacterial siderophore-binding protein FepB.

Interleukin-17 (IL-17)-induced microRNA 873 (miR-873) contributes to the pathogenesis of experimental autoimmune encephalomyelitis by targeting A20 ubiquitin-editing enzyme.

Natural antisense transcript for hyaluronan synthase 2 (HAS2-AS1) induces transcription of HAS2 via protein O-GlcNAcylation.

Biogenesis of lysosome-related organelles complex-1 subunit 1 (BLOS1) interacts with sorting nexin 2 and the endosomal sorting complex required for transport-I (ESCRT-I) component TSG101 to mediate the sorting of epidermal growth factor receptor into endosomal compartments.

Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors.

Induction of the unfolded protein response by constitutive G-protein signaling in rod photoreceptor cells.

Signal transduction triggered by iron to induce the nuclear importation of a Myb3 transcription factor in the parasitic protozoan Trichomonas vaginalis.

Phosphorylation by Casein Kinase 2 Facilitates Psh1 Protein-assisted Degradation of Cse4 $Protein^{*}$

Mycobacterium tuberculosis promotes anti-apoptotic activity of the macrophage by PtpA protein-dependent dephosphorylation of host GSK3 .

Activation of LTBP3 gene by a long noncoding RNA (lncRNA) MALAT1 transcript in mesenchymal stem cells from multiple myeloma.

Translocation of Glycogen Synthase Kinase-3β (GSK-3β), a Trigger of Permeability Transition, Is Kinase Activity-dependent and Mediated by Interaction with Voltage-dependent Anion Channel 2 (VDAC2)

The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D.

Synthetic Phosphopeptides Enable Quantitation of the Content and Function of the Four Phosphorylation States of Phospholamban in Cardiac Muscle

A combined transgenic proteomic analysis and regulated trafficking of neuroligin-2.

Large conductance voltage- and Ca2+-gated potassium (BK) channel ß4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases.

Zinc-binding domain-dependent, deaminase-independent actions of apolipoprotein B mRNA-editing enzyme, catalytic polypeptide 2 (Apobec2), mediate its effect on zebrafish retina regeneration.

Structural asymmetry of the terminal catalytic complex in selenocysteine synthesis.

Physical and Functional Interactions between the Histone H3K4 Demethylase KDM5A and the Nucleosome Remodeling and Deacetylase (NuRD) Complex

Stromal Interaction Molecule 1 (STIM1) and Orai1 Mediate Histamine-evoked Calcium Entry and Nuclear Factor of Activated T-cells (NFAT) Signaling in Human Umbilical Vein Endothelial Cells

Up-regulation of the Sirtuin 1 (Sirt1) and peroxisome proliferator-activated receptor Î³ coactivator-1 (PGC-1 ) genes in white adipose tissue of Id1 protein-deficient mice: implications in the protection against diet and age-induced glucose intolerance.

Ring finger protein 34 (RNF34) interacts with and promotes Î³-aminobutyric acid type-A receptor degradation via ubiquitination of the Î³2 subunit.

Enhanced in vivo efficacy of a type I interferon superagonist with extended plasma half-life in a mouse model of multiple sclerosis.

Critical Roles of Interdomain Interactions for Modulatory ATP Binding to Sarcoplasmic Reticulum $Ca^{2+}-ATPase$

Identification of redox partners and development of a novel chimeric bacterial nitric oxide synthase for structure activity analyses.

A Cytosolic Relay of Heat Shock Proteins HSP70-1A and HSP90β Monitors the Folding Trajectory of the Serotonin $Transporter^{*}$

Post-translational regulation of mitogen-activated protein kinase phosphatase (MKP)-1 and MKP-2 in macrophages following lipopolysaccharide stimulation: the role of the C termini of the phosphatases in determining their stability.

Essential role of protein-tyrosine phosphatase 1B in the modulation of insulin signaling by acetaminophen in hepatocytes.

Transforming growth factor ß1 (TGF-ß1) enhances expression of profibrotic genes through a novel signaling cascade and microRNAs in renal mesangial cells.

The Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Active Site and Cleavage Sequence Differentially Regulate Protein Secretion from Proteolysis

Year: 2014 Volume: 289 Issue: 41

Year: 2014 Volume: 289 Issue: 40

Year: 2014 Volume: 289 Issue: 39

Year: 2014 Volume: 289 Issue: 38

Year: 2014 Volume: 289 Issue: 37

Year: 2014 Volume: 289 Issue: 36

Year: 2014 Volume: 289 Issue: 35

Year: 2014 Volume: 289 Issue: 34

Year: 2014 Volume: 289 Issue: 33

Year: 2014 Volume: 289 Issue: 32

Year: 2014 Volume: 289 Issue: 31

Year: 2014 Volume: 289 Issue: 30

Year: 2014 Volume: 289 Issue: 29

Year: 2014 Volume: 289 Issue: 28

Year: 2014 Volume: 289 Issue: 27

Year: 2014 Volume: 289 Issue: 26

Year: 2014 Volume: 289 Issue: 25

Year: 2014 Volume: 289 Issue: 24

Year: 2014 Volume: 289 Issue: 23

Year: 2014 Volume: 289 Issue: 22

Year: 2014 Volume: 289 Issue: 21

Year: 2014 Volume: 289 Issue: 20

Year: 2014 Volume: 289 Issue: 19

Year: 2014 Volume: 289 Issue: 18

Year: 2014 Volume: 289 Issue: 17

Year: 2014 Volume: 289 Issue: 16

Year: 2014 Volume: 289 Issue: 15

Year: 2014 Volume: 289 Issue: 14

Year: 2014 Volume: 289 Issue: 13

Year: 2014 Volume: 289 Issue: 12

Year: 2014 Volume: 289 Issue: 11

Year: 2014 Volume: 289 Issue: 10

Year: 2014 Volume: 289 Issue: 9

Year: 2014 Volume: 289 Issue: 8

Year: 2014 Volume: 289 Issue: 7

Year: 2014 Volume: 289 Issue: 6

Year: 2014 Volume: 289 Issue: 5

Year: 2014 Volume: 289 Issue: 4

Year: 2014 Volume: 289 Issue: 3

Year: 2014 Volume: 289 Issue: 2

Year: 2014 Volume: 289 Issue: 1

Year: 2013 Volume: 288

Year: 2012 Volume: 287

Year: 2011 Volume: 286

Year: 2010 Volume: 285

Year: 2009 Volume: 284

Year: 2008 Volume: 283

Year: 2007 Volume: 282

Year: 2006 Volume: 281

Year: 2005 Volume: 280

Year: 2004 Volume: 279

Year: 2003 Volume: 278

Year: 2002 Volume: 277

Year: 2001 Volume: 276

Year: 2000 Volume: 275

Year: 1999 Volume: 274

Year: 1998 Volume: 273

Year: 1997 Volume: 272

Year: 1996 Volume: 271

Year: 1995 Volume: 270

Year: 1994 Volume: 269

Year: 1993 Volume: 268

Year: 1992 Volume: 267

Year: 1991 Volume: 266

Year: 1990 Volume: 265

Year: 1989 Volume: 264

Year: 1988 Volume: 263

Year: 1987 Volume: 262

Year: 1986 Volume: 261

Year: 1984 Volume: 259

Year: 1982 Volume: 257

Year: 1981 Volume: 256

Year: 1975 Volume: 250

Genome-wide approaches reveal functional vascular endothelial growth factor (VEGF)-inducible nuclear factor of activated T cells (NFAT) c1 binding to angiogenesis-related genes in the endothelium.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Suehiro, Jun-ichi Miura, Mai Manabe, Yuuka Kodama, Tatsuhiko Kanki, Yasuharu Minami, Takashi Schadler, Keri Aburatani, Hiroyuki Makihara, Chihiro
Description	Author Affiliation: Suehiro J ( From the Division of Vascular Biology.); Kanki Y ( From the Division of Vascular Biology, Systems Biology, The Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, 153-8904 Japan and.); Makihara C ( From the Division of Vascular Biology.); Schadler K ( From the Division of Vascular Biology, the Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104.); Miura M ( From the Division of Vascular Biology.); Manabe Y ( From the Division of Vascular Biology.); Aburatani H ( Genome Science Division, and.); Kodama T ( Systems Biology, The Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, 153-8904 Japan and.); Minami T ( From the Division of Vascular Biology, minami@med.rcast.u-tokyo.ac.jp.)
Abstract	VEGF is a key regulator of endothelial cell migration, proliferation, and inflammation, which leads to activation of several signaling cascades, including the calcineurin-nuclear factor of activated T cells (NFAT) pathway. NFAT is not only important for immune responses but also for cardiovascular development and the pathogenesis of Down syndrome. By using Down syndrome model mice and clinical patient samples, we showed recently that the VEGF-calcineurin-NFAT signaling axis regulates tumor angiogenesis and tumor metastasis. However, the connection between genome-wide views of NFAT-mediated gene regulation and downstream gene function in the endothelium has not been studied extensively. Here we performed comprehensive mapping of genome-wide NFATc1 binding in VEGF-stimulated primary cultured endothelial cells and elucidated the functional consequences of VEGF-NFATc1-mediated phenotypic changes. A comparison of the NFATc1 ChIP sequence profile and epigenetic histone marks revealed that predominant NFATc1-occupied peaks overlapped with promoter-associated histone marks. Moreover, we identified two novel NFATc1 regulated genes, CXCR7 and RND1. CXCR7 knockdown abrogated SDF-1- and VEGF-mediated cell migration and tube formation. siRNA treatment of RND1 impaired vascular barrier function, caused RhoA hyperactivation, and further stimulated VEGF-mediated vascular outgrowth from aortic rings. Taken together, these findings suggest that dynamic NFATc1 binding to target genes is critical for VEGF-mediated endothelial cell activation. CXCR7 and RND1 are NFATc1 target genes with multiple functions, including regulation of cell migration, tube formation, and barrier formation in endothelial cells.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	42
Volume Number	289
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2014-10-17
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Endothelium, Vascular Metabolism NFATC Transcription Factors Neovascularization, Pathologic Vascular Endothelial Growth Factor A Animals COS Cells Cell Movement Cercopithecus Aethiops Coculture Techniques Endothelial Cells Cytology Epigenesis, Genetic Fibroblasts Genome-Wide Association Study HEK293 Cells Homeostasis Human Umbilical Vein Endothelial Cells Mice Oligonucleotide Array Sequence Analysis Phenotype Receptors, CXCR4 Signal Transduction Transcriptional Activation Rho GTP-Binding Proteins Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in