NDLI: Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RI activation in response to cAMP binding.

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Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RI activation in response to cAMP binding.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mcculloch, Andrew D. Boras, Britton W. Kornev, Alexandr Taylor, Susan S.
Description	Author Affiliation: Boras BW ( From the Departments of Bioengineering.); Kornev A ( Chemistry and Biochemistry.); Taylor SS ( Chemistry and Biochemistry, Pharmacology, and.); McCulloch AD ( From the Departments of Bioengineering, Medicine, University of California, San Diego, La Jolla, California 92093 amcculloch@ucsd.edu.)
Abstract	Protein kinase A (PKA) holoenzyme consists of two catalytic (C) subunits and a regulatory (R) subunit dimer (R(2)C(2)). The kinase is activated by the binding of cAMPs to the two cyclic nucleotide binding domains (CBDs), A and B, on each R-subunit. Despite extensive study, details of the allosteric mechanisms underlying the cooperativity of holoenzyme activation remain unclear. Several Markov state models of PKA-RI were developed to test competing theories of activation for the R(2)C(2) complex. We found that CBD-B plays an essential role in R-C interaction and promotes the release of the first C-subunit prior to the binding to CBD-A. This favors a conformational selection mechanism for release of the first C-subunit of PKA. However, the release of the second C-subunit requires all four cAMP sites to be occupied. These analyses elucidate R-C heterodimer interactions in the cooperative activation of PKA and cAMP binding and represent a new mechanistic model of R(2)C(2) PKA-RI activation.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	43
Volume Number	289
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2014-10-24
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cyclic AMP-Dependent Protein Kinase RIalpha Subunit Metabolism Cyclic AMP Markov Chains Models, Molecular Chemistry Enzyme Activation Drug Effects Mutant Proteins Oligopeptides Pharmacology Protein Multimerization Protein Structure, Tertiary Reproducibility Of Results Research Support, N.I.H., Extramural Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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