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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Guo, Liang Tang, Qi-qun Li, Xi |
| Description | Author Affiliation: Guo L ( From the Key Laboratory of Metabolism and Molecular Medicine, the Ministry of Education and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai 200032, China.); Li X ( From the Key Laboratory of Metabolism and Molecular Medicine, the Ministry of Education and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai 200032, China.); Tang QQ ( From the Key Laboratory of Metabolism and Molecular Medicine, the Ministry of Education and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai 200032, China qqtang@shmu.edu.cn.) |
| Abstract | A detailed understanding of the processes controlling adipogenesis is instrumental in the fight against the obesity epidemic. Adipogenesis is controlled by a transcriptional cascade composed of a large number of transcriptional factors, among which CCAAT/enhancer-binding protein (C/EBP) ß plays an essential role. During 3T3-L1 adipocyte differentiation, C/EBPß is induced early to transactivate the expression of C/EBP and peroxisome proliferator-activated receptor γ (PPARγ), two master transcription factors for terminal adipocyte differentiation. Studies in recent years have revealed many new target genes of C/EBPß, implicating its participation in many other processes during adipogenesis, such as mitotic clonal expansion, epigenetic regulation, unfolded protein response, and autophagy. Moreover, the function of C/EBPß is highly regulated by post-translational modifications, which are crucial for the proper activation of the adipogenic program. Advances toward elucidation of the function and roles of the post-translational modification of C/EBPß during adipogenesis will greatly improve our understanding of the molecular mechanisms governing adipogenesis. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 2 |
| Volume Number | 290 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2015-01-09 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Adipocytes Metabolism Adipogenesis Genetics CCAAT-Enhancer-Binding Protein-beta Cell Differentiation Animals Autophagy Cell Proliferation Epigenomics Protein Processing, Post-Translational Unfolded Protein Response Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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