NDLI: Porous nanocomposites of PEG-PLA / calcium phosphate : room-temperature synthesis and its application in drug delivery

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Ke-wei Zhu, Ying-jie Duan, You-rong Wang, Qi Cao, Shao-wen Chen, Feng Tang, Qi-li Wu, Jin
Description	Author Affiliation: Tang QL ( State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.)
Abstract	We report room-temperature preparation of poly(ethylene glycol)-block-polylactide ( PEG-PLA )/ calcium phosphate ( CP ) nanocomposites with a porous morphology. The reaction time and concentration of the inorganic ingredients play an important role in the morphology and chemical composition of the nanocomposite. Thermogravimetry analysis shows that there is approximately 8.5 wt.% of PEG-PLA block copolymer in the nanocomposite. A typical anti-inflammatory drug , ibuprofen , is used to evaluate the drug loading ability and the release behavior of the porous PEG-PLA / CP nanocomposite. The experiments reveal that the nanocomposite has a higher drug loading capacity and favorable drug release property. The drug release kinetics of the porous PEG-PLA / CP nanocomposite is discussed as a three-stage process. The as-prepared porous PEG-PLA / CP nanocomposite is promising for application in drug delivery.
ISSN	14779226
Issue Number	18
Volume Number	39
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2010-05-14
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Calcium Phosphates Chemistry Drug Carriers Chemical Synthesis Nanocomposites Polyesters Polyethylene Glycols Anti-Inflammatory Agents, Non-Steroidal Administration & Dosage Ibuprofen Kinetics Porosity Temperature Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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