NDLI: Synthesis and DNA photocleavage study of Ru(bpy) $_{3}$ $^{2+}$ $-(CH_{2})

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pang, Yi Sun, Licheng He, Yanxia Fan, Jiangli Sun, Shiguo Liu, Fengyu Peng, Xiaojun Yang, Zhigang
Description	Author Affiliation: Sun S ( State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 158-40, Zhongshanlu, Xigang District, 116012, Dalian, China.)
Abstract	A series of Ru(bpy) $_{3}$ $^{2+}$ $-(CH_{2})_{n}-MV^{2+}$ complexes (1, n = 3, 4, 7) used for DNA photocleavage have been designed and synthesized. Under the irradiation of visible light, complexes 1 can cleave supercoiled plasmid DNA (pBR322) both in air and under Ar atmosphere. Radical species such as $O_{2}^{−}˙,$ ˙OH and the light-induced charge-separated (CS) oxidation state Ru(bpy) $_{3}$ $^{3+}$ $-(CH_{2})_{n}-MV^{+}˙$ are responsible for the cleavage. The longer the carbon chain linkage, the higher the DNA photocleavage efficiency. It is noted that backwards intramolecular electron transfer (ET) that exist in complexes 1 can lead to some decreasing effect on the cleavage result, while inclusion of complexes 1 with cucurbit[8]uril ( CB[8] ) inhibits the backwards ET to some extent, thereby increasing photocleavage efficiency.
ISSN	14779226
Issue Number	18
Volume Number	39
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2010-05-14
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Coordination Complexes Chemical Synthesis DNA Chemistry Organometallic Compounds Ruthenium Viologens Metabolism DNA Cleavage Electron Transport Photolysis Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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