NDLI: $YVO_{4}:Eu^{3+}$ functionalized porous silica submicrospheres as delivery carriers of doxorubicin

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$YVO_{4}:Eu^{3+}$ functionalized porous silica submicrospheres as delivery carriers of doxorubicin

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$YVO_{4}:Eu^{3+}$ functionalized porous silica submicrospheres as delivery carriers of doxorubicin

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhai, Xuefeng Hou, Zhiyao Wang, Wenxin Lin, Jun Ma, Pingan Cheng, Ziyong Dai, Yunlu
Description	Author Affiliation: Cheng Z ( State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.)
Abstract	Porous silica microspheres were fabricated by a facile surface-protected etching strategy. Polyvinylpyrrolidone (PVP) was used as a protecting polymer absorbed on the surface of silica microspheres and NaOH was employed as an etching agent. Owing to the protective action of PVP and inhomogeneous etching , mesopores were created in the silica microspheres. Then, based on the Pechini-type sol–gel and impregnating process, $YVO_{4}:Eu^{3+}$ nanocrystals were integrated into the channels to form highly luminescent $YVO_{4}:Eu^{3+}@SiO_{2}$ composite microspheres. The biocompatibility tests on L929 fibroblast cells using MTT assay reveal low cytotoxicity of the system. Owing to the large interior space and electrostatic interaction, the porous microspheres show a relatively high loading capacity (438 mg $DOX/YVO_{4}:Eu^{3+}@SiO_{2}$ g) and encapsulation efficiency (87.6%) for the anti-cancer drug doxorubicin hydrochloride (DOX). The drug release behavior and cytotoxic effect against human cervical carcinoma cells (HeLa cells) of the DOX-loaded $YVO_{4}:Eu^{3+}@SiO_{2}$ carriers were investigated in vitro. It was found that the carriers present a highly pH-dependent drug release behavior due to electrostatic interaction between the silica surface and DOX molecules. The drug release rate became greater at low pH owing to the increased electrostatic repulsion. The DOX-loaded carriers demonstrate a similar or even greater anti-cancer activity with respect to the free DOX against HeLa cells. Furthermore, the PL intensity of the microspheres shows correlation with the cumulative release of DOX. These results suggest that the composite can potentially act as a multifunctional drug carrier system with luminescent tagging and pH-controlled release properties.
ISSN	14779226
Issue Number	5
Volume Number	41
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2012-02-07
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Antibiotics, Antineoplastic Administration & Dosage Doxorubicin Drug Carriers Chemistry Europium Silicon Dioxide Vanadates Yttrium Animals Pharmacology Biocompatible Materials Cell Line HeLa Cells Humans Mice Porosity Povidone Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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