NDLI: Uniform and size-tunable mesoporous silica with fibrous morphology for drug delivery

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yang, Piaoping Zhang, Milin Gai, Shili Ma, Ping'an Wang, Liuzhen Li, Chunxia Jun, Lin
Description	Author Affiliation: Gai S ( Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, Harbin Engineering University, Harbin, China.)
Abstract	A family of mesoporous silica microspheres with fibrous morphology and different particle sizes ranging from about 400 to 900 nm has been successfully synthesized through a facile self-assembly process. The structural, morphological, and textural properties of the samples were well characterized by scanning electron microscopy ( SEM ), transmission electron microscopy ( TEM ), nuclear magnetic resonance ( NMR ), Fourier transform infrared spectroscopy ( FT-IR ), $N_{2}$ adsorption/desorption, and thermal gravimetry ( TG ). The results reveal that this silica-based mesoporous material exhibits excellent physical properties, including a fibrous spherical morphology, good thermal stability, large pore volume, high specific surface area and narrow size distribution. Additionally, the size and textural properties can be tuned by altering the silica precursor/template molar ratio. The formation and the self-assembly evolution process have also been proposed. The obtained materials were further used as a drug delivery carrier to investigate the in vitro drug release properties using doxorubicin (DOX) as a representative model drug . It was found that this kind of silica exhibits good biocompatibility and obvious sustained drug release properties, suggesting its potential application in biological fields.
ISSN	14779226
Issue Number	15
Volume Number	41
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2012-04-21
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Antibiotics, Antineoplastic Administration & Dosage Doxorubicin Drug Carriers Chemistry Silicon Dioxide Animals Cell Line Cell Survival Cercopithecus Aethiops Microscopy, Electron, Scanning Microscopy, Electron, Transmission Microspheres Particle Size Porosity Spectroscopy, Fourier Transform Infrared Vero Cells Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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