NDLI: Copper(I) complexes with phosphine derived from sparfloxacin. Part I – structures, spectroscopic properties and cytotoxicity

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jezowska-bojczuk, Malgorzata Starosta, Radoslaw Kyziol, Agnieszka Komarnicka, Urszula K.
Description	Author Affiliation: Komarnicka UK ( Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland. malgorzata.jezowska-bojczuk@chem.uni.wroc.pl.)
Abstract	In this paper we present new copper(I) iodide or copper(I) thiocyanate complexes with hydroxymethyldiphenylphosphine $(PPh_{2}(CH_{2}OH))$ or phosphine derivatives of sparfloxacin, a $3^{rd}$ generation fluoroquinolone antibiotic agent $(PPh_{2}(CH_{2}–Sf))$ and 2,9-dimethyl-1,10-phenanthroline (dmp) or 2,2′-biquinoline (bq) auxiliary ligands. The synthesised complexes were fully characterised by NMR and UV-Vis spectroscopy as well as by mass spectrometry. Selected structures were additionally analysed using X-ray and DFT methods. All complexes proved to be stable in solution in the presence of water and atmospheric oxygen for several days. The cytotoxic activity of the complexes was tested against two cancer cell lines (CT26 – mouse colon carcinoma and A549 – human lung adenocarcinoma). Applying two different incubation times, the studies enabled a preliminary estimation of the dependence of the selectivity and the mechanism of action on the type of diimine and phosphine ligands. The results obtained showed that complexes with $PPh_{2}(CH_{2}–Sf)$ are significantly more active than those with $PPh_{2}(CH_{2}OH).$ On the other hand, the relative impact of diimine on cytotoxicity is less pronounced. However, the dmp complexes are characterised by strong inhibitory properties, while the bq ones are rather not. This confirms the interesting and promising biological properties of the investigated group of copper(I) complexes, which undoubtedly are worthy of further biological studies.
ISSN	14779226
Issue Number	28
Volume Number	44
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2015-07-28
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Coordination Complexes Copper Iodides Phenanthrolines Phosphines Quinolines Thiocyanates Animals Cell Line, Tumor Cell Survival Drug Effects Chemistry Pharmacology Crystallography, X-Ray Fluoroquinolones Humans Ligands Magnetic Resonance Spectroscopy Mice Spectrophotometry, Ultraviolet Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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