NDLI: Formation constants of copper(I) complexes with cysteine, penicillamine and glutathione: implications for copper speciation in the human eye

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Formation constants of copper(I) complexes with cysteine, penicillamine and glutathione: implications for copper speciation in the human eye

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hefter, Glenn May, Peter M. Königsberger, Erich Königsberger, Lan-chi
Description	Author Affiliation: Königsberger LC ( Chemical and Metallurgical Engineering and Chemistry, School of Engineering and Information Technology, Murdoch University, Murdoch WA 6150, Australia. L.Koenigsberger@murdoch.edu.au E.Koenigsberger@murdoch.edu.au G.Hefter@murdoch.edu.au P.May@murdoch.edu.au.)
Abstract	Protonation constants for the biologically-important thioamino acids cysteine (CSH), penicillamine (PSH) and glutathione (GSH), and the formation constants of their complexes with Cu(I), have been measured at 25 °C and an ionic strength of 1.00 mol $dm^{−3}$ (Na)Cl using glass electrode potentiometry. The first successful characterisation of binary Cu(I)−CSH and Cu(I)−GSH species over the whole pH range was achieved in this study by the addition of a second thioamino acid, which prevented the precipitation that normally occurs. Appropriate combinations of binary and ternary (mixed ligand) titration data were used to optimise the speciation models and formation constants for the binary species. The results obtained differ significantly from literature data with respect to the detection and quantification of protonated and polynuclear complexes. The present results are thought to be more reliable because of the exceptionally wide pH and concentration ranges employed, the excellent reproducibility of the data, the close agreement between the calculated and observed formation functions, and the low standard deviations and absence of numerical correlation in the constants. The present formation constants were incorporated into a large Cu speciation model which was used to predict, for the first time, metal–ligand equilibria in the biofluids of the human eye. This simulation provided an explanation for the precipitation of metallic copper in lens and cornea, which is known to occur as a consequence of Wilson's disease.
ISSN	14779226
Issue Number	47
Volume Number	44
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2015-12-21
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Coordination Complexes Chemistry Copper Cysteine Glutathione Models, Biological Penicillamine Computer Simulation Eye Humans Hydrogen-Ion Concentration Potentiometry Journal Article
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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