NDLI: Biological activity and coordination modes of copper( II) complexes of Schiff base -derived coumarin ligands

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kellett, Andrew Devereux, Michael Rockenbauer, Antal Szabó-plánka, Terézia Walsh, Maureen Mcclean, Siobhán Nagy, Nóra Veronika Czeglédi, Eszter Foltyn-arfa Kia, Agnieszka Noble, Andy Enyedy, Éva Anna Karcz, Dariusz Creaven, Bernadette Sarah
Description	Author Affiliation: Creaven BS ( Department of Science, Institute of Technology Tallaght, Dublin 24, Ireland.)
Abstract	The coordination modes of copper( II) complexes of Schiff base -derived coumarin ligands, which had previously shown good anti-Candida activity, were investigated by pH-potentiometric and UV-Vis spectroscopic methods. These studies confirmed the coordination mode of the ligands to be through the N of the imine and deprotonated phenol of the coumarin-derived ligand in solution. In addition, the more active complexes and their corresponding ligands were investigated in the presence of copper( II) in liquid and frozen solution by ESR spectroscopic methods. A series of secondary amine derivatives of the Schiff base ligands, were isolated with good solubility characteristics but showed little anti-Candida activity. However, cytotoxicity studies of the secondary amines , together with the copper complexes and their corresponding ligands, against human colon cancer and human breast cancer cells identified the chemotherapeutic potential of these new ligands.
ISSN	14779226
Issue Number	45
Volume Number	39
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2010-12-07
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Copper Chemistry Coumarins Organometallic Compounds Pharmacology Schiff Bases Amines Anti-Infective Agents Chemical Synthesis Antineoplastic Agents Bacteria Drug Effects Candida Cell Line, Tumor Electron Spin Resonance Spectroscopy Humans Hydrogen-Ion Concentration Ligands Potentiometry Solubility Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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