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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chantarasriwong, Oraphin Batova, Ayse Chavasiri, Warinthorn Theodorakis, Emmanuel A. |
| Description | Author Affiliation: Chantarasriwong O ( Department of Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.) |
| Abstract | Natural products have been a great source of many small molecule drugs for various diseases. In spite of recent advances in biochemical engineering and fermentation technologies that allow us to explore microorganisms and the marine environment as alternative sources of drugs, more than 70 % of the current small molecule therapeutics derive their structures from plants used in traditional medicine. Natural-product-based drug discovery relies heavily on advances made in the sciences of biology and chemistry. Whereas biology aims to investigate the mode of action of a natural product, chemistry aims to overcome challenges related to its supply, bioactivity, and target selectivity. This review summarizes the explorations of the caged Garcinia xanthones, a family of plant metabolites that possess a unique chemical structure, potent bioactivities, and a promising pharmacology for drug design and development. |
| ISSN | 09476539 |
| e-ISSN | 15213765 |
| Journal | Chemistry - A European Journal |
| Issue Number | 33 |
| Volume Number | 16 |
| Language | English |
| Publisher | Wiley-VCH;ChemPubSoc Europe |
| Publisher Date | 2010-09-03 |
| Publisher Place | Germany |
| Access Restriction | Open |
| Subject Keyword | Garcinia Chemistry Xanthones Pharmacology Animals Plant Extracts Structure-Activity Relationship Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Catalysis |
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