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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lukes, Ivan Jendelová, Pavla Hermann, Petr Jirák, Daniel Berková, Zuzana Kotková, Zuzana Kotek, Jan Herynek, Vít |
| Description | Author Affiliation: Kotková Z ( Department of Inorganic Chemistry, Univerzita Karlova v Praze (Charles University in Prague), Hlavova 2030, 128 40 Praha 2, Czech Republic.) |
| Abstract | A novel bimodal fluorescence/MRI probe based on a cyclodextrin scaffold has been synthesized and characterized. The final agent employs the fluorescein (F) functionality as a fluorescence marker and the $Gd^{III}$ complex of a macrocyclic DOTA-based ligand (GdL) having one aminobenzyl-phosphinic acid pendant arm as an MRI probe, and has a statistical composition of $(GdL)_{6.9}-F_{0.1}-β-CD.$ Slow rotational dynamics (governed by a very rigid cyclodextrin scaffold) combined with fast water exchange (ensured by the chosen macrocyclic ligand) resulted in a high relaxivity of $∼22 s^{−1} mM^{−1}$ per $Gd^{III}$ or $∼150 s^{−1} mM^{−1}$ per molecule of the final conjugate (20 MHz, 25 °C). In vitro labelling of pancreatic islets (PIs) and rat mesenchymal stem cells has been successfully performed. The agent is not cytotoxic and is easily internalized into cells. The labelled cells can be visualized by MRI, as proved by the detection of individual labelled PIs. A fluorescence study performed on mesenchymal stem cells showed that the agent stays in the intracellular space for a long time. |
| ISSN | 09476539 |
| e-ISSN | 15213765 |
| Journal | Chemistry - A European Journal |
| Issue Number | 33 |
| Volume Number | 16 |
| Language | English |
| Publisher | Wiley-VCH;ChemPubSoc Europe |
| Publisher Date | 2010-09-03 |
| Publisher Place | Germany |
| Access Restriction | Open |
| Subject Keyword | Contrast Media Chemistry Cyclodextrins Magnetic Resonance Imaging Animals Fluoresceins Fluorescent Dyes Gadolinium Models, Molecular Organometallic Compounds Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Catalysis |
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