NDLI: Highly Water-Dispersible Surface-Modified $Gd_{2}O_{3}$ Nanoparticles for Potential Dual-Modal Bioimaging

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Highly Water-Dispersible Surface-Modified $Gd_{2}O_{3}$ Nanoparticles for Potential Dual-Modal Bioimaging

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Highly Water-Dispersible Surface-Modified $Gd_{2}O_{3}$ Nanoparticles for Potential Dual-Modal Bioimaging

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Skoglund, Caroline Selegård, Linnéa Hu, Zhangjun Söderlind, Fredrik Ahrén, Maria Zhang, Xuanjun Engström, Maria Uvdal, Kajsa
Abstract	Water-dispersible and luminescent gadolinium oxide (GO) nanoparticles (NPs) were designed and synthesized for potential dual-modal biological imaging. They were obtained by capping gadolinium oxide nanoparticles with a fluorescent glycol-based conjugated carboxylate (HL). The obtained nanoparticles (GO-L) show long-term colloidal stability and intense blue fluorescence. In addition, L can sensitize the luminescence of europium(III) through the so-called antenna effect. Thus, to extend the spectral ranges of emission, europium was introduced into L-modified gadolinium oxide nanoparticles. The obtained $Eu^{III}-doped$ particles (Eu:GO-L) can provide visible red emission, which is more intensive than that without L capping. The average diameter of the monodisperse modified oxide cores is about 4 nm. The average hydrodynamic diameter of the L-modified nanoparticles was estimated to be about 13 nm. The nanoparticles show effective longitudinal water proton relaxivity. The relaxivity values obtained for GO-L and Eu:GO-L were $r_{1}=6.4$ and $6.3 s^{−1} mM^{−1}$ with $r_{2}/r_{1}$ ratios close to unity at 1.4 T. Longitudinal proton relaxivities of these nanoparticles are higher than those of positive contrast agents based on gadolinium complexes such as Gd-DOTA, which are commonly used for clinical magnetic resonance imaging. Moreover, these particles are suitable for cellular imaging and show good biocompatibility.
ISSN	09476539
e-ISSN	15213765
Journal	Chemistry - A European Journal
Issue Number	38
Volume Number	19
Language	English
Publisher	Wiley-VCH;ChemPubSoc Europe
Publisher Date	2013-09-16
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	Contrast Media Chemistry Gadolinium Metal Nanoparticles Cell Survival Drug Effects Chemical Synthesis Toxicity Europium HeLa Cells Heterocyclic Compounds, 1-Ring Magnetic Resonance Imaging Ultrastructure Microscopy, Confocal Surface Properties Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

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