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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Spiteller, Dieter Paetz, Christian Behrend, Anne Morgenstern, Anne |
| Description | Author Affiliation: Morgenstern A ( Max Planck Institute for Chemical Ecology, Hans Knöll Strasse 8, 07745 Jena (Germany).) |
| Abstract | The bacterium Streptomyces coelicolor M145 reacts to transition-metal-ion stress with myriad growth responses, leading to different phenotypes. In particular, in the presence of $Co^{2+}$ ions (0.7 mM) S. coelicolor consistently produced a red phenotype. This phenotype, when compared to the wild type, differed strongly in its production of volatile compounds as well as high molecular weight secondary metabolites. LC-MS analysis revealed that in the red phenotype the production of the prodigiosins, undecylprodigiosin and streptorubin B, was strongly induced and, in addition, several intense signals appeared in the LC-MS chromatogram. Using LC-MS/MS and NMR spectroscopy, two new prodigiosin derivatives were identified, that is, coeligiosin A and B, which contained an additional undecylpyrrolyl side chain attached to the central carbon of the tripyrrole ring system of undecylprodigiosin or streptorubin B. This example demonstrates that environmental factors such as heavy metal ion stress can not only induce the production of otherwise not observed metabolites from so called sleeping genes but alter the products from well-studied biosynthetic pathways. |
| ISSN | 09476539 |
| e-ISSN | 15213765 |
| Journal | Chemistry - A European Journal |
| Issue Number | 16 |
| Volume Number | 21 |
| Language | English |
| Publisher | Wiley-VCH;ChemPubSoc Europe |
| Publisher Date | 2015-04-13 |
| Publisher Place | Germany |
| Access Restriction | Open |
| Subject Keyword | Anti-Bacterial Agents Metabolism Cobalt Prodigiosin Analogs & Derivatives Streptomyces Coelicolor Research Support, Non-U.S. Gov't Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Catalysis |
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