NDLI: Expanding the Scope of $2′-SCF_{3}$ Modified RNA

Please wait, while we are loading the content...

Year: 2017 Volume: 23

Year: 2016 Volume: 22

Year: 2015 Volume: 21

Year: 2015 Volume: 21 Issue: 52

Year: 2015 Volume: 21 Issue: 51

Year: 2015 Volume: 21 Issue: 50

Year: 2015 Volume: 21 Issue: 49

Year: 2015 Volume: 21 Issue: 48

Year: 2015 Volume: 21 Issue: 47

Year: 2015 Volume: 21 Issue: 46

Year: 2015 Volume: 21 Issue: 45

Year: 2015 Volume: 21 Issue: 44

Year: 2015 Volume: 21 Issue: 43

Year: 2015 Volume: 21 Issue: 42

Year: 2015 Volume: 21 Issue: 41

Year: 2015 Volume: 21 Issue: 40

Year: 2015 Volume: 21 Issue: 39

Year: 2015 Volume: 21 Issue: 38

Year: 2015 Volume: 21 Issue: 37

Year: 2015 Volume: 21 Issue: 36

Year: 2015 Volume: 21 Issue: 35

Year: 2015 Volume: 21 Issue: 34

Year: 2015 Volume: 21 Issue: 33

Year: 2015 Volume: 21 Issue: 32

Year: 2015 Volume: 21 Issue: 31

Year: 2015 Volume: 21 Issue: 30

Year: 2015 Volume: 21 Issue: 29

Recent Progress towards Transition-Metal-Catalyzed Synthesis of Fluorenes

Chiral Iminophosphoranes—An Emerging Class of Superbase Organocatalysts

Electrophilic Addition to Alkenes: The Relation between Reactivity and Enthalpy of Hydrogenation: Regioselectivity is Determined by the Stability of the Two Conceivable Products

Fluorescent Silica Nanoparticles with Multivalent Inhibitory Effects towards Carbonic Anhydrases

Synthesis and Mechanistic Study of Cyclic Oxoguanidines via $Zn(OTf)_{2}-Catalyzed$ Guanylation/Amidation from Readily Available Amino Acid Esters and Carbodiimides

Combined Spectroscopic and Electrochemical Detection of a $Ni^{I}⋅⋅⋅HN$ Bonding Interaction with Relevance to Electrocatalytic $H_{2}$ Production

Mononuclear Polypyridylruthenium(II) Complexes with High Membrane Permeability in Gram-Negative Bacteria—in particular Pseudomonas aeruginosa

Chiral $N,O-Ligand/[Cu(OAc)_{2}]-Catalyzed$ Asymmetric Construction of 4-Aminopyrrolidine Derivatives by 1,3-Dipolar Cycloaddition of Azomethine Ylides with α-Phthalimidoacrylates

A Series of Lanthanide Metal–Organic Frameworks with Interesting Adjustable Photoluminescence Constructed by Helical Chains

Anion- and Spacer-Directed Host–Guest Complexes of Bipyridine with Pyrogallol[4]arene

Isolation of $CeLu_{2}N@I_{h}-C_{80}$ through a Non-Chromatographic, Two-Step Chemical Process and Crystallographic Characterization of the Pyramidalized $CeLu_{2}N$ within the Icosahedral Cage

A Highly Efficient Chirality Switchable Synthesis of Dihydropyran-Fused Benzofurans by Fine-Tuning the Phenolic Proton of β-Isocupreidine (β-ICD) Catalyst with Methyl

Fluorescent Silica Nanoparticles with Multivalent Inhibitory Effects towards Carbonic Anhydrases

Computational (DFT) and Experimental (EXAFS) Study of the Interaction of $[Ir(IMes)(H)_{2}(L)_{3}]$ with Substrates and Co-substrates Relevant for SABRE in Dilute $Systems^{†}$

Controllable Preparation of Polyaniline–Graphene Nanocomposites using Functionalized Graphene for Supercapacitor Electrodes

Asymmetric Isothiourea-Catalysed Formal [3+2] Cycloadditions of Ammonium Enolates with Oxaziridines

Strong Direct Magnetic Coupling in a Dinuclear $Co^{II}$ Tetrazine Radical Single-Molecule Magnet

Surface Functionalization of $g-C_{3}N_{4}:$ Molecular-Level Design of Noble-Metal-Free Hydrogen Evolution Photocatalysts

Facial Synthesis of o-Carborane-Substituted Alkenes and Allenes by a Regioselective Ene Reaction of 1,3-Dehydro-o-carborane

The Key Role of the Nonchelating Conformation of the Benzylidene Ligand on the Formation and Initiation of Hoveyda–Grubbs Metathesis Catalysts

Expanding the Scope of $2′-SCF_{3}$ Modified RNA

Synthesis, Characterization, and Repair of a Flexible $O^{6}-2′-Deoxyguanosine-alkylene-O^{6}-2′-deoxyguanosine$ Intrastrand Cross-Link

Polyoxomolybdate Bisphosphonate Heterometallic Complexes: Synthesis, Structure, and Activity on a Breast Cancer Cell Line

Group 2 Catalysis for the Atom-Efficient Synthesis of Imidazolidine and Thiazolidine Derivatives

Dendrimers with Oligospiroketal (OSK) Building Blocks: Synthesis and Properties

Fabrication of Efficient Hydrogenation Nanoreactors by Modifying the Freedom of Ultrasmall Platinum Nanoparticles within Yolk–Shell Nanospheres

Total Synthesis, Stereochemical Revision, and Biological Reassessment of Mandelalide A: Chemical Mimicry of Intrafamily Relationships

The Structure and Conformation of $(CH_{3})_{3}CSNO$

Chiral Iodine-Catalyzed Dearomatizative Spirocyclization for the Enantioselective Construction of an All-Carbon Stereogenic Center

Cysteine-Mediated Intracellular Building of Luciferin to Enhance Probe Retention and Fluorescence Turn-On

Highly Segregated Lamello-Columnar Mesophase Organizations and Fast Charge Carrier Mobility in New Discotic Donor–Acceptor Triads

Synergistic Stereocontrol in the Enantioselective Ruthenium-Catalyzed Sulfoxidation of Spirodithiolane-Indolones

Metal–Organic Frameworks (MOFs) as Multivalent Materials: Size Control and Surface Functionalization by Monovalent Capping Ligands

A Tetraferrocenyl-Resorcinarene Cavitand as a Redox-Switchable Host of Ammonium Salts

A Modular Approach To Study Protein Adsorption on Surface Modified Hydroxyapatite

Visible-Light-Driven Intermolecular [2+2] Cycloadditions between Coumarin-3-Carboxylates and Acrylamide Analogs

Fluorescent Pyrene-Based Bis-azole Compounds: Synthesis and Photophysical Analysis

Surface-Functionalized Nanoparticles by Olefin Metathesis: A Chemoselective Approach for In Vivo Characterization of Atherosclerosis Plaque

Conformational Plasticity in Glycomimetics: Fluorocarbamethyl-L-idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings

Dynamic Formation of Noncovalent Calixsalen Aggregates

Palladium/Copper-Cocatalyzed Oxidative Amidobrominations of Alkenes

Year: 2015 Volume: 21 Issue: 28

Year: 2015 Volume: 21 Issue: 27

Year: 2015 Volume: 21 Issue: 26

Year: 2015 Volume: 21 Issue: 25

Year: 2015 Volume: 21 Issue: 24

Year: 2015 Volume: 21 Issue: 23

Year: 2015 Volume: 21 Issue: 22

Year: 2015 Volume: 21 Issue: 21

Year: 2015 Volume: 21 Issue: 20

Year: 2015 Volume: 21 Issue: 19

Year: 2015 Volume: 21 Issue: 18

Year: 2015 Volume: 21 Issue: 17

Year: 2015 Volume: 21 Issue: 16

Year: 2015 Volume: 21 Issue: 15

Year: 2015 Volume: 21 Issue: 14

Year: 2015 Volume: 21 Issue: 13

Year: 2015 Volume: 21 Issue: 12

Year: 2015 Volume: 21 Issue: 11

Year: 2015 Volume: 21 Issue: 10

Year: 2015 Volume: 21 Issue: 9

Year: 2015 Volume: 21 Issue: 8

Year: 2015 Volume: 21 Issue: 7

Year: 2015 Volume: 21 Issue: 6

Year: 2015 Volume: 21 Issue: 5

Year: 2015 Volume: 21 Issue: 4

Year: 2015 Volume: 21 Issue: 3

Year: 2015 Volume: 21 Issue: 2

Year: 2015 Volume: 21 Issue: 1

Year: 2014 Volume: 20

Year: 2013 Volume: 19

Year: 2012 Volume: 18

Year: 2011 Volume: 17

Year: 2010 Volume: 16

Year: 2009 Volume: 15

Year: 2008 Volume: 14

Year: 2007 Volume: 13

Year: 2006 Volume: 12

Year: 2005 Volume: 11

Year: 1997 Volume: 3

Expanding the Scope of $2′-SCF_{3}$ Modified RNA

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hartl, Markus Kreutz, Christoph Bister, Klaus Kosutic, Marija Jud, Lukas Schwarz, Veronika Micura, Ronald
Description	Author Affiliation: Jud L ( Institute of Organic Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020 Innsbruck (Austria).); Kosutic M ( Institute of Organic Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020 Innsbruck (Austria).); Schwarz V ( Institute of Organic Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020 Innsbruck (Austria).); Hartl M ( Institute of Biochemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020 Innsbruck (Austria).); Kreutz C ( Institute of Organic Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020 Innsbruck (Austria).); Bister K ( Institute of Biochemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020 Innsbruck (Austria).); Micura R ( Institute of Organic Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020 Innsbruck (Austria). ronald.micura@uibk.ac.at.)
Abstract	The 2′-trifluoromethylthio $(2′-SCF_{3})$ modification endows ribonucleic acids with exceptional properties and has attracted considerable interest as a reporter group for NMR spectroscopic applications. However, only modified pyrimidine nucleosides have been generated so far. Here, the syntheses of $2′-SCF_{3}$ adenosine and guanosine phosphoramidites of which the latter was obtained in highly efficient manner by an unconventional Boc-protecting group strategy, are reported. RNA solid-phase synthesis provided site-specifically $2′-SCF_{3}-modified$ oligoribonucleotides that were investigated intensively. Their excellent behavior in $^{19}F NMR$ spectroscopic probing of RNA ligand binding was exemplified for a noncovalent small molecule–RNA interaction. Moreover, comparably to the $2′-SCF_{3}$ pyrimidine nucleosides, the purine counterparts were also found to cause a significant thermodynamic destabilization when located in double helical regions. This property was considered beneficial for siRNA design under the aspect to minimize off-target effects and their performance in silencing of the BASP1 gene was demonstrated.
ISSN	09476539
e-ISSN	15213765
Journal	Chemistry - A European Journal
Issue Number	29
Volume Number	21
Language	English
Publisher	Wiley-VCH;ChemPubSoc Europe
Publisher Date	2015-07-13
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	Fluorine Chemistry Oligonucleotides Organophosphorus Compounds Purines RNA, Small Interfering Crystallography, X-Ray Ligands Magnetic Resonance Spectroscopy Metabolism Solid-Phase Synthesis Techniques Thermodynamics Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in