NDLI: Caspase 3 Targeted Cargo Delivery in Apoptotic Cells Using Capped Mesoporous Silica Nanoparticles

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Caspase 3 Targeted Cargo Delivery in Apoptotic Cells Using Capped Mesoporous Silica Nanoparticles

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Caspase 3 Targeted Cargo Delivery in Apoptotic Cells Using Capped Mesoporous Silica Nanoparticles

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	De La Torre, Cristina Sancenón, Félix Orzáez, Mar Martínez-máñez, Ramón Pérez-payá, Enrique Coll, Carmen García-fernández, Alba Mondragón, Laura Amorós, Pedro
Description	Author Affiliation: de la Torre C ( Centro de Reconocimiento Molecular y Desarrollo Tecnológico Unidad, Mixta Universidad Politécnica de Valencia Universidad de Valencia, Camino de Vera s/n, 46022, Valencia (Spain).); Mondragón L ( Departamento de Química, Universidad Politécnica de Valencia, Camino de Vera s/n, 46022, Valencia (Spain).); Coll C ( CIBER de Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN) (Spain).); García-Fernández A ( Centro de Reconocimiento Molecular y Desarrollo Tecnológico Unidad, Mixta Universidad Politécnica de Valencia Universidad de Valencia, Camino de Vera s/n, 46022, Valencia (Spain).); Sancenón F ( Departamento de Química, Universidad Politécnica de Valencia, Camino de Vera s/n, 46022, Valencia (Spain).); Martínez-Máñez R ( CIBER de Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN) (Spain).); Amorós P ( Centre Méditerranéen de Médecine Moléculaire (C3M) - Equipe 'Contrôle métabolique des morts cellulaires', Université Nice Sophia Antipolis, Institut national de la santé et de la recherche médicale (Inserm), U1065, BP 2 3194, 06204, Nice (France).); Pérez-Payá E ( Centro de Reconocimiento Molecular y Desarrollo Tecnológico Unidad, Mixta Universidad Politécnica de Valencia Universidad de Valencia, Camino de Vera s/n, 46022, Valencia (Spain).); Orzáez M ( Departamento de Química, Universidad Politécnica de Valencia, Camino de Vera s/n, 46022, Valencia (Spain).)
Abstract	Excessive apoptotic cell death is at the origin of several pathologies, such as degenerative disorders, stroke or ischemia-reperfusion damage. In this context, strategies to improve inhibition of apoptosis and other types of cell death are of interest and may represent a pharmacological opportunity for the treatment of cell-death-related disorders. In this scenario new peptide-containing delivery systems (solids $S_{1}-P_{1}$ and $S_{1}-P_{2})$ are described based on mesoporous silica nanoparticles (MSNs) loaded with a dye and capped with the KKGDEVDKKARDEVDK $(P_{1})$ peptide that contains two repeats of the DEVD target sequence that are selectively hydrolyzed by caspase 3 (C3). This enzyme plays a central role in the execution-phase of apoptosis. HeLa cells electroporated with $S_{1}–P_{1}$ are able to deliver the cargo in the presence of staurosporin (STS), which induces apoptosis with the consequent activation of the cytoplasmic C3 enzyme. Moreover, the nanoparticles $S_{1}-P_{2},$ containing both a cell-penetrating TAT peptide and $P_{1}$ also entered in HeLa cells and delivered the cargo preferentially in cells treated with the apoptosis inducer cisplatin.
ISSN	09476539
e-ISSN	15213765
Journal	Chemistry - A European Journal
Issue Number	44
Volume Number	21
Language	English
Publisher	Wiley-VCH;ChemPubSoc Europe
Publisher Date	2015-10-26
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	Caspase 3 Chemistry Metabolism Cisplatin Drug Carriers Nanoparticles Silicon Dioxide Apoptosis HeLa Cells Porosity Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

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