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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Robinson, C. Hoult, J. R. |
| Abstract | 1 U46619, a prostaglandin H2 endoperoxide analogue and thromboxane A2 agonist, dose-dependently inhibited accumulation and metabolism of thromboxane B2 in the isolated perfused lung of the guinea-pig. At similar doses prostaglandins E1, E2, F1 alpha, F2 alpha, I2, 5, 6-trans-PGE2 and 8-iso-PGE1 were ineffective. 2 U46619 did not affect accumulation and metabolism of prostaglandin F2 alpha under similar conditions. 3 The pulmonary disposition of thromboxane B2, which occurs by uptake into pulmonary cells or binding to a specific macromolecular component, is mediated by a mechanism distinct from that handling prostaglandin F2 alpha. The possible relevance of these findings to the pulmonary disposition of thromboxane A2 is discussed. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 1 |
| Volume Number | 78 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1983-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Lung Metabolism Prostaglandins Pharmacology Thromboxane B2 Thromboxanes 15-Hydroxy-11 Alpha,9 Alpha-(epoxymethano)prosta-5,13-dienoic Acid Animals Guinea Pigs In Vitro Techniques Inulin Prostaglandin Endoperoxides, Synthetic |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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