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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zappia, L. Bertaccini, G. |
| Abstract | 1 The possible temperature-dependent interconversion of histamine H1- and H2-receptors in the guinea-pig ileum suggested from previous studies was re-investigated by use of new and selective H2-receptor agonists and antagonists. 2 Chlorpheniramine, and H1-blocker, caused a rightward shift of the cumulative histamine dose-response curve at both 37 degrees C and 12 degrees C. Conversely cimetidine and tiotidine, two H2-receptor blockers, were ineffective at both temperatures. Metiamide behaved as a non competitive antagonist at 12 degrees C but only in very high concentrations. 3 Dimaprit and impromidine, two selective H2-receptor agonists, were inactive at both 37 degrees C and 12 degrees C when given alone, whereas at both temperatures they elicited the already described relaxation of the contractions induced by histamine. 4 Similar results were obtained on the guinea-pig whole ileum and on the longitudinal muscle strip: this indicates a lack of interference of the circular smooth muscle. 5 Our results allow us to conclude that no temperature-dependent interconversion of histamine H1- and H2-receptors occurs in the guinea-pig ileum. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 1 |
| Volume Number | 78 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1983-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Muscle, Smooth Metabolism Receptors, Histamine H1 Physiology Receptors, Histamine H2 Receptors, Histamine Animals Guinea Pigs Histamine Pharmacology Histamine H1 Antagonists Histamine H2 Antagonists Ileum In Vitro Techniques Kinetics Temperature Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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