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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bertolini, A. Guarini, S. Bazzani, C. |
| Description | Author Affiliation: Guarini S ( Institute of Pharmacology, University of Modena, Italy.) |
| Abstract | 1. In a rat model of volume-controlled haemorrhagic shock causing the death of all control (saline-treated) animals within 30 min, the intravenous (i.v.) bolus injection of ACTH-(1-24) at a dose of 160 micrograms kg-1 produced an impressive and sustained restoration of arterial pressure, pulse pressure and respiratory function, with 100% survival at the end of the observation period (2 h). 2. Both intracerebroventricular (i.c.v., 0.015-0.06 microgram kg-1) and i.v. (5 micrograms kg-1) pretreatment with the N-calcium channel blocker, omega-conotoxin GVIA, and i.v. (but not i.c.v.) pretreatment with the L-calcium channel blocker, nicardipine (125-500 micrograms kg-1) dose-dependently prevented the ACTH-induced shock reversal. 3. These results further indicate that the effect of ACTH in haemorrhagic shock may involve a neuronal link and the eventual restoration of vascular tone mediated by N- and L-type calcium channels, respectively. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 3 |
| Volume Number | 109 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1993-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Adrenocorticotropic Hormone Pharmacology Calcium Channel Blockers Calcium Channels Drug Effects Muscle, Smooth, Vascular Neurons Shock, Hemorrhagic Physiopathology Antagonists & Inhibitors Animals Blood Pressure Dose-Response Relationship, Drug Injections, Intravenous Injections, Intraventricular Nicardipine Peptides Rats, Wistar Respiration Omega-Conotoxin GVIA Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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