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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Velasco, C. Salvador, T. San Román, L. Morán, A. Martín, M. L. |
| Description | Author Affiliation: Morán A ( Departamento de Fisiología y Farmacología, Facultad de Farmacia, Universidad de Salamanca, Spain.) |
| Abstract | 1. A study was made of the effects of 5-hydroxytryptamine (5-HT) on pressor response induced in vivo by electrical stimulation of the sympathetic outflow from the spinal cord of pithed rats. All animals had been pretreated with atropine. Intravenous infusion of 5-hydroxytryptamine at doses of 10 and 20 micrograms kg-1 min-1 reduced the pressor effects obtained by electrical stimulation at intervals of 10 min over the 1 h of infusion. 2. This inhibitory action of 5-HT was depressed by cyproheptadine and methiothepin but was not modified by ketanserin or MDL-72222. By contrast, the inhibitory action of 5-HT was lost in pithed rats that had been pretreated with exogenous noradrenaline. 3. The 5-HT1 receptor agonist 5-carboxamidotryptamine (5-CT) caused an inhibition of the pressor response, whereas the 5-HT3 receptor agonist, 1-phenylbiguanide, produced a variable but significant increase in the pressor response. The 5-HT2 receptor agonist, m-CPP, did not modify the pressor sympathetic response. 4. Our results suggest that 5-hydroxytryptamine interferes with sympathetic neurotransmission by inhibiting pressor effects as a result of stimulation of the complete sympathetic outflow, and that this inhibition is mainly through a presynaptic 5-HT1 mechanism. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 4 |
| Volume Number | 113 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1994-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Blood Pressure Drug Effects Decerebrate State Physiopathology Receptors, Serotonin Physiology Spinal Cord Sympathetic Nervous System Animals Atropine Pharmacology Electric Stimulation Muscle, Smooth, Vascular Norepinephrine Rats, Wistar Serotonin Serotonin Antagonists Serotonin Receptor Agonists |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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