NDLI: Diabetes-induced changes in the 5-hydroxytryptamine inhibitory receptors involved in the pressor effect elicited by sympathetic stimulation in the pithed rat

Content Provider	PubMed Central
Author	García, Mónica Morán, Asunción Calama, Elena Martín, Maria Luisa Mariette, Barthelmebs Román, Luis San
Copyright Year	2005
Abstract	We investigated the effect of alloxan-induced diabetes on the inhibitory mechanisms of 5-hydroxytryptamine (5-HT) in the pressor responses induced by stimulation of sympathetic vasopressor outflow in pithed rats, and analysed the type and/or subtype of 5-HT receptors involved. Diabetes was induced in male Wistar rats by a single s.c. injection of alloxan, then 4 weeks later, they were anaesthetized, pretreated with atropine and pithed. Electrical stimulation of the sympathetic outflow from the spinal cord (0.1, 0.5, 1 and 5 Hz) resulted in frequency-dependent increases in blood pressure. Intravenous infusions of 5-HT (1–80 μg kg−1 min−1) reduced the pressor effects obtained by electrical stimulation. The 5-HT1 receptor agonist 5-carboxamidotryptamine, 5-CT (5 μg kg−1 min−1), caused an inhibition of the pressor response, whereas the selective 5-HT2 receptor agonist, α-methyl-5-HT (5 μg kg−1 min−1) and the selective 5-HT3 receptor agonist, 1-phenylbiguanide (40 μg kg−1 min−1), did not modify the sympathetic pressor responses. 5-HT had no effect on exogenous noradrenaline (NA)-induced pressor responses. The inhibition of electrically induced pressor responses by 5-HT (10 μg kg−1 min−1) was unable to be elicited after i.v. treatment with methiothepin (100 μg kg−1) because of the marked inhibition produced by methiothepin alone. The 5-HT-induced inhibition was blocked after i.v. administration of WAY-100,635 (100 μg kg−1) and not affected by ritanserin (1 mg kg−1), MDL 72222 (2 mg kg−1). The selective 5-HT1A receptor agonist, 8-hydroxydipropylaminotretalin hydrobromide (8-OH-DPAT) (5–20 μg kg−1 min−1) but neither the rodent 5-HT1B receptor agonist, CGS-12066B (5 μg kg−1 min−1), nor the selective nonrodent 5-HT1B and 5-HT1D receptor agonist, L-694,247 (5 and 40 μg kg−1 min−1), inhibited the electrically induced pressor response. The selective 5-HT1A receptor antagonist, WAY-100,635 (100 μg kg−1), blocked the inhibition induced by 8-OH-DPAT (10 μg kg−1 min−1). 8-OH-DPAT had no effect on exogenous NA-induced pressor responses. Experimental diabetes produces changes in the inhibitory effect induced by 5-HT on electrically induced sympathetic pressor responses, such that the inhibitory action induced by 5-HT in diabetic pithed rats is mediated by prejunctional 5-HT1A receptors.
Related Links	http://dx.doi.org/10.1038/sj.bjp.0706216
Ending Page	601
Page Count	9
Starting Page	593
File Format	PDF
ISSN	00071188
Journal	British Journal of Pharmacology
Issue Number	5
Volume Number	145
Language	English
Publisher Date	2005-07-01
Access Restriction	Open
Subject Keyword	Pharmacology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pharmacology

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Diabetes-induced changes in the 5-hydroxytryptamine inhibitory receptors involved in the pressor effect elicited by sympathetic stimulation in the pithed rat.

Characterization of prejunctional 5-HT1 receptors that mediate the inhibition of pressor effects elicited by sympathetic stimulation in the pithed rat

Inhibitory 5-hydroxytryptamine receptors involved in pressor effects obtained by stimulation of sympathetic outflow from spinal cord in pithed rats.

Characterization of prejunctional 5-HT1 receptors that mediate the inhibition of pressor effects elicited by sympathetic stimulation in the pithed rat.

Inhibitory effects of clonidine on responses to sympathetic nerve stimulation in the pithed rat.

Inhibitory action of niflumic acid on noradrenaline- and 5-hydroxytryptamine-induced pressor responses in the isolated mesenteric vascular bed of the rat

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Characterization of prejunctional 5-HT receptors mediating inhibition of sympathetic vasopressor responses in the pithed rat.

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Diabetes-induced changes in the 5-hydroxytryptamine inhibitory receptors involved in the pressor effect elicited by sympathetic stimulation in the pithed rat

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