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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hasebe, Nobuyoshi Hosoi, Rie Yamaguchi, Masatoshi Inoue, Osamu Sugiyama, Eriko Abe, Kohji Tsuchiya, Noriko Gee, Antony |
| Description | Author Affiliation: Inoue O ( Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka, Japan. inoue@sahs.med.osaka-u.ac.jp) |
| Abstract | BACKGROUND AND PURPOSE: A ketogenic diet has been used successfully to treat patients with intractable epilepsy, although the mechanism is unknown. Acetone has been shown to have an anticonvulsive effect in various animal models. The main purpose of this study was to determine whether other ketones, 2-butanone (methyl ethyl ketone: MEK) and 3-pentanone (diethyl ketone: DEK), also show anticonvulsive effects in lithium-pilocarpine (Li-pilocarpine)-induced status epilepticus (SE) in rats. EXPERIMENTAL APPROACH: Anticonvulsive effects of MEK and DEK in Li-pilocarpine SE rats were measured by behavioural scoring. Anti-seizure effects of MEK were also evaluated using electroencephalography (EEG). Neuroprotective effect of MEK was investigated by haematoxylin and eosin staining 4 weeks after the treatment with pilocarpine. KEY RESULTS: Acetone, MEK and DEK showed anticonvulsant effects in Li-pilocarpine-induced SE rats. Treatment with MEK twice (8 mmol.kg(-1) and 5 mmol.kg(-1)) almost completely blocked spontaneous recurrent cortical seizure EEG up to 4 weeks after the administration of pilocarpine. MEK also showed strong neuroprotective effects in Li-pilocarpine-treated rats 4 weeks following the administration of pilocarpine. Significant neural cell death occurred in the hippocampus of Li-pilocarpine SE rats, especially in the CA1 and CA3 subfields. In contrast, normal histological characteristics were observed in these regions in the MEK-pretreated rats. CONCLUSIONS AND IMPLICATIONS: Both MEK and DEK showed strong anticonvulsive effects in Li-pilocarpine-induced SE rats. They also inhibited continuous recurrent seizure and neural damage in hippocampal region for 4 weeks after the treatment with pilocarpine. These findings appear to be of value in the investigation of epilepsy. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 3 |
| Volume Number | 158 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 2009-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Anticonvulsants Therapeutic Use Butanones Lithium Chloride Pilocarpine Status Epilepticus Drug Therapy Acetone Animals Hippocampus Drug Effects Pathology Ketogenic Diet Neuroprotective Agents Pentanones Rats, Wistar Chemically Induced Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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