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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | de Freitas, Rivelilson Mendes de Oliveira Silva, Fábio Saldanha, Gláucio Barros Jordán, Joaquín |
| Description | Country affiliation: Brazil Author Affiliation: de Freitas RM ( Laboratory of Experimental Research in Biological Sciences of Federal University of Piauí, Piauí, Brazil. rivelilson@pq.cnpq.br) |
| Abstract | This study was aimed at investigating the anticonvulsant activity of lipoic acid (LA) against pilocarpine-induced seizures as well as the effects of this metabolic antioxidant on the hippocampal extracellular concentrations of amino acid neurotransmitters glutamate, aspartate, glycine and glutamate and γ-aminobutyric acid (GABA). In vivo microdialysis demonstrated that an intraperitoneal administration of pilocarpine induced a pronounced increment of hippocampal glutamate and aspartate concentrations, whereas no significant change was observed in the levels of glycine or GABA. LA (10, 20 or 30 mg/kg) pretreatment completely blocked pilocarpine-evoked increases in extracellular glutamate and aspartate concentrations. Significant reductions in hippocampal GABA and glycine concentrations were also observed although not as pronounced as those shown by glutamate and aspartate. Based on the finding that LA protected rats against pilocarpine-induced seizures, it could be suggested that the reduction in inhibitory amino acid neurotransmitters levels was comparatively minor and offset by a more pronounced reduction in glutamate and aspartate extracellular concentrations. Therefore, the fact that LA could drastically reduce pilocarpine-induced increases in glutamate and aspartate should account, at least partly, for its anticonvulsant activity observed in pilocarpine-induced seizure in rats. |
| File Format | HTM / HTML |
| ISSN | 07673981 |
| Issue Number | 4 |
| Volume Number | 25 |
| e-ISSN | 14728206 |
| Journal | Fundamental & Clinical Pharmacology |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2011-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Excitatory Amino Acids Cerebrospinal Fluid Hippocampus Metabolism Pilocarpine Pharmacology Seizures Thioctic Acid Animals Anticonvulsants Therapeutic Use Aspartic Acid Dialysis Methods Glutamic Acid Glycine Drug Effects Male Rats Rats, Wistar Chemically Induced Mortality Physiopathology Prevention & Control Status Epilepticus Survival Analysis Gamma-aminobutyric Acid Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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