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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kannan, Natarajan Taylor, Susan S. Neuwald, Andrew F. |
| Description | Author Affiliation: Kannan N ( Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0654, USA. kannan@ucsd.edu) |
| Abstract | The precise positioning of the flexible C-helix in the catalytic core is a critical step in the activation of most protein kinases. Consequently, the alphaC-beta4 loop, which anchors the C-helix to the catalytic core, is highly conserved and mediates key structural interactions that serve as a hinge for C-helix movement. While these hinge interactions are conserved across diverse eukaryotic protein kinase structures, some families such as AGC kinases diverge from the canonical hinge interactions. This divergence was recently proposed to facilitate an alternative mode of regulation wherein a conserved C-terminal tail interacts with the alphaC-beta4 loop to position the C-helix. Here we show how interactions between the alphaC-beta4 loop and the N-terminal SH2 domain of ZAP-70 tyrosine kinase are mechanistically and functionally analogous to interactions between the alphaC-beta4 loop and the C-terminal tail of AGC kinases. Such cis regulation of protein kinase activity may be a feature of other eukaryotic protein kinase families as well. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 1 |
| Volume Number | 1784 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Protein Kinases Chemistry Metabolism ZAP-70 Protein-Tyrosine Kinase Amino Acid Motifs Animals Catalytic Domain Cyclic AMP-Dependent Protein Kinases Cyclic GMP-Dependent Protein Kinases Genetics Intracellular Signaling Peptides And Proteins MAP Kinase Kinase 1 Protein Kinase C Protein Structure, Secondary Protein Structure, Tertiary Protein Subunits Protein-Tyrosine Kinases Receptor, ErbB-2 Src Homology Domains Research Support, N.I.H., Extramural Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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