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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bonechi, Claudia Rossi, Claudio Ristori, Sandra Martini, Giacomo Martini, Silvia |
| Description | Author Affiliation: Bonechi C ( Department of Chemical and Biosystem Sciences and CSGI, University of Siena, Via A. Moro 2, 53100 Siena, Italy. cbonechi@unisi.it) |
| Abstract | The conformation of bradykinin (BK), Arg1-Pro2-Pro3-Gly4-Phe5-Ser6-Pro7-Phe8-Arg9, was investigated by Nuclear Magnetic Resonance (NMR) spectroscopy and Monte Carlo simulation in two different media, i.e. in pure aqueous solution and in the presence of phospholipid vesicles. Monolamellar liposomes are a good model for biological membranes and mimic the environment experienced by bradykinin when interacting with G-protein coupled receptors (GPCRs). The NMR spectra showed that lipid bilayers induced a secondary structure in the otherwise inherently flexible peptide. The results of ensemble calculations revealed conformational changes occurring rapidly on the NMR time scale and allowed for the identification of different families of conformations that were averaged to reproduce the NMR observables. These structural results supported the hypothesis of the central role played by the peptide C-terminal domain in biological environments, and provided an explanation for the different biological behaviours observed for bradykinin. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 3 |
| Volume Number | 1788 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Bradykinin Chemistry Computer Simulation Liposomes Models, Molecular Nuclear Magnetic Resonance, Biomolecular Phosphatidylcholines Phosphatidylethanolamines Protein Conformation Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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