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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Blume, Alfred Arouri, Ahmad Dathe, Margitta |
| Description | Author Affiliation: Arouri A ( Martin-Luther-University Halle-Wittenberg, Institute of Chemistry, Muehlpforte 1, D-06108 Halle/Saale, Germany.) |
| Abstract | Antimicrobial peptides attract a lot of interest as potential candidates to overcome bacterial resistance. So far, nearly all the proposed scenarios for their mechanism of action are associated with perforating and breaking down bacterial membranes after a binding process. In this study we obtained additional information on peptide induced demixing of bacterial membranes as a possible mechanism of specificity of antimicrobial peptides. We used DSC and FT-IR to study the influence of a linear and cyclic arginine- and tryptophan-rich antimicrobial peptide having the same sequence (RRWWRF) on the thermotropic phase transitions of lipid membranes. The cyclization of the peptide was found to enhance its antimicrobial activity and selectivity ( Dathe, M. Nikolenko, H. Klose, J. Bienert, M. Biochemistry 43 (2004) 9140–9150). A particular preference of the binding of the peptides to DPPG headgroups compared to other headgroups of negatively charged phospholipids, namely DMPA, DPPS and cardiolipin was observed. The main transition temperature of DPPG bilayers was considerably decreased by the bound peptides. The peptides caused a substantial down-shift of the transition of DPPG/DMPC. In contrast, they induced a demixing in DPPG/DPPE bilayers and led to the appearance of two peaks in the DSC curves indicating a DPPG-peptide-enriched domain and a DPPE-enriched domain. These results could be confirmed by FT-IR-spectroscopic measurements. We therefore propose that the observed peptide-induced lipid demixing in PG/PE-membranes could be a further specific effect of the antimicrobial peptides operating only on bacterial membranes, which contain appreciable amounts of PE and PG, and which could in principle also occur in liquid–crystalline membranes. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 3 |
| Volume Number | 1788 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Antimicrobial Cationic Peptides Chemistry Lipid Bilayers Phosphatidylethanolamines Phosphatidylglycerols Anti-Infective Agents Pharmacology Bacteria Drug Effects Calorimetry, Differential Scanning Membranes, Artificial Models, Molecular Spectroscopy, Fourier Transform Infrared Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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