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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Walther, Dirk M. Rapaport, Doron |
| Description | Author Affiliation: Walther DM ( Interfakultäres Institut für Biochemie, Hoppe-Seyler-Str. 4, University of Tübingen, 72076 Tübingen, Germany.) |
| Abstract | Mitochondria are surrounded by two distinct membranes: the outer and the inner membrane. The mitochondrial outer membrane mediates numerous interactions between the mitochondrial metabolic and genetic systems and the rest of the eukaryotic cell. Proteins of this membrane are nuclear-encoded and synthesized as precursor proteins in the cytosol. They are targeted to the mitochondria and inserted into their target membrane via various pathways. This review summarizes our current knowledge of the sorting signals for this specific targeting and describes the mechanisms by which the mitochondrial import machineries recognize precursor proteins, mediate their membrane integration and facilitate assembly into functional complexes. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 1 |
| Volume Number | 1793 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Mitochondrial Membrane Transport Proteins Metabolism Mitochondrial Membranes Animals Carrier Proteins Chemistry Genetics Evolution, Molecular Models, Biological Structure-Activity Relationship Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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