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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Park, Joung-sun Yamaguchi, Masamitsu Kim, Young-shin Park, So-young Lee, Shin-hae Yoo, Mi-ae Kim, Joong-gook |
| Description | Author Affiliation: Park JS ( Department of Molecular Biology, Pusan National University, Busan 609-735, Korea.) |
| Abstract | The Drosophila midgut is an excellent model for evaluation of gene networks that regulate adult stem cell proliferation and differentiation. The Drosophila p38b (D-p38b) gene has been shown to be involved in intestinal stem cell (ISC) proliferation and differentiation in the adult midgut. Here, we report that D-p38b gene expression is regulated by DREF (DNA replication-related element binding factor) in the adult midgut. We have identified a DRE in the 5′-flanking region of the D-p38b gene and showed that DREF could bind to this DRE via a gel mobility shift assay and a ChIP assay. Base-substitution mutations of the D-p38b promoter DRE and analyses of transformants carrying D-p38b-lacZ or D-p38b-DREmut-lacZ indicated that this DRE is required for the activity of the D-p38b gene promoter. Furthermore, by using the GAL4-UAS system, we showed that DREF regulates the activity of the D-p38b gene promoter in adult ISCs and progenitors. In addition, the D-p38b knockdown phenotypes in the midgut were rescued by DREF overexpression, suggesting a functional link between these two factors. Our results suggest that the D-p38b gene is regulated by the DREF pathway and that DREF is involved in the regulation of proliferation and differentiation of Drosophila ISCs and progenitors. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 7 |
| Volume Number | 1799 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-07-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Drosophila Proteins Genetics Drosophila Melanogaster Metabolism Gene Expression Regulation Intestines Mitogen-Activated Protein Kinase 11 Transcription Factors Animals Animals, Genetically Modified Cell Lineage Green Fluorescent Proteins Models, Biological Mutation Phenotype Promoter Regions, Genetic Stem Cells Cytology Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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