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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Athanassiou, G. Giannopoulou, E. Kalofonos, H. P. Kritikou, I. Siatis, K. E. Metsiou, D. Papachristou, D. J. Kalofonou, M. Koutras, A. |
| Description | Author Affiliation: Giannopoulou E ( Clinical Oncology laboratory, Division of Oncology, Department of Medicine, University of Patras, Rion, Patra 26504, Greece.); Siatis KE ( Clinical Oncology laboratory, Division of Oncology, Department of Medicine, University of Patras, Rion, Patra 26504, Greece.); Metsiou D ( Laboratory of Biomechanics and Biomedical Engineering, Department of Mechanical Engineering and Aeronautics, University of Patras, Rion, Patra 26504, Greece.); Kritikou I ( Clinical Oncology laboratory, Division of Oncology, Department of Medicine, University of Patras, Rion, Patra 26504, Greece.); Papachristou DJ ( Department of Anatomy-Histology-Embryology, Unit of Bone and Soft Tissue Studies, Department of Medicine, University of Patras, Rion, 26504, Greece.); Kalofonou M ( Clinical Oncology laboratory, Division of Oncology, Department of Medicine, University of Patras, Rion, Patra 26504, Greece.); Koutras A ( Clinical Oncology laboratory, Division of Oncology, Department of Medicine, University of Patras, Rion, Patra 26504, Greece.); Athanassiou G ( Laboratory of Biomechanics and Biomedical Engineering, Department of Mechanical Engineering and Aeronautics, University of Patras, Rion, Patra 26504, Greece. Electronic address: gathan@mech.upatras.gr.); Kalofonos HP ( Clinical Oncology laboratory, Division of Oncology, Department of Medicine, University of Patras, Rion, Patra 26504, Greece. Electronic address: kalofonos@upatras.gr.) |
| Abstract | Tumor invasion and metastasis are key aspects of non-small cell lung cancer (NSCLC). During migration, cells undergo mechanical alterations. The mechanical phenotype of breast cancer cells is correlated with aromatase gene expression. We have previously shown that targeting aromatase is a promising strategy for NSCLC. The aim of this study was to examine morphological and mechanical changes of NSCLC cells, upon treatment with aromatase inhibitor and correlate their ability to migrate and invade. In vitro experiments were performed using H23 and A549 NSCLC cell lines and exemestane was used for aromatase inhibition. We demonstrated that exemestane reduced H23 cell migration and invasion and caused changes in cell morphology including increased vacuolar structures and greater pleomorphism. In addition, exemestane changed the distribution of α-tubulin in H23 and A549 cells in a way that might destabilize microtubules polymerization. These effects were associated with increased cell viscosity and decreased elastic shear modulus. Although exemestane caused similar effects in A549 cells regarding viscosity and elastic shear modulus, it did not affect A549 cell migration and caused an increase in invasion. The increased invasion was in line with vimentin perinuclear localization. Our data show that the treatment of NSCLC cells with an aromatase inhibitor not only affects cell migration and invasion but also alters the mechanical properties of the cells. It suggests that the different origin of cancer cells is associated with different morphological characteristics and mechanical behavior. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 2 |
| Volume Number | 1853 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-02-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Aromatase Inhibitors Pharmacology Aromatase Metabolism Carcinoma, Non-Small-Cell Lung Enzymology Pathology Cell Movement Drug Effects Lung Neoplasms Rheology Actins Androstadienes Therapeutic Use Apoptosis Biomechanical Phenomena Drug Therapy Ultrastructure Cell Line, Tumor Cell Shape Cytoskeleton Elastic Modulus Neoplasm Invasiveness Tubulin Vimentin Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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