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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kim, Nam-hyung Rui, Rong Wang, Fei Liu, Hong-lin Cui, Xiang-shun Zhang, Yu Niu, Ying-jie Sun, Shao-chen |
| Description | Author Affiliation: Zhang Y ( College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.); Wang F ( College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.); Niu YJ ( College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.); Liu HL ( College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.); Rui R ( College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.); Cui XS ( Department of Animal Sciences, Chungbuk National University, Cheongju, Chungbuk, 361-763, Republic of Korea.); Kim NH ( Department of Animal Sciences, Chungbuk National University, Cheongju, Chungbuk, 361-763, Republic of Korea.); Sun SC ( College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China. Electronic address: sunsc@njau.edu.cn.) |
| Abstract | Mammalian diaphanous1 (mDia1) is a homologue of Drosophila diaphanous and belongs to the Formin-homology family of proteins that catalyze actin nucleation and polymerization. Although Formin family proteins, such as Drosophila diaphanous, have been shown to be essential for cytokinesis, whether and how mDia1 functions during meiosis remain uncertain. In this study, we explored possible roles and the signaling pathway involved for mDia1 using a mouse oocyte model. mDia1 depletion reduced polar body extrusion, which may have been due to reduced cortical actin assembly. mDia1 and Profilin1 had similar localization patterns in mouse oocytes and mDia1 knockdown resulted in reduced Profilin1 expression. Depleting FMNL1, another Formin family member, resulted in reduced mDia1 expression, while RhoA inhibition did not alter mDia1 expression, which indicated that there was a FMNL1-mDia1-Profilin1 signaling pathway in mouse oocytes. Additionally, mDia1 knockdown resulted in disrupting oocyte spindle morphology, which was confirmed by aberrant p-MAPK localization. Thus, these results demonstrated indispensable roles for mDia1 in regulating mouse oocyte meiotic maturation through its effects on actin assembly and spindle organization. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 2 |
| Volume Number | 1853 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-02-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Actins Metabolism Carrier Proteins Intracellular Signaling Peptides And Proteins Meiosis Oocytes Cytology Profilins Spindle Apparatus Animals Chromosomes, Mammalian Gene Knockdown Techniques Mice, Inbred ICR Models, Biological Polar Bodies Subcellular Fractions RhoA GTP-Binding Protein Antagonists & Inhibitors Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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