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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Baumert, Thomas F. Lupberger, Joachim Colpitts, Che C. Doerig, Christian |
| Description | Author Affiliation: Colpitts CC ( Inserm U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France); Lupberger J ( Inserm U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France); Doerig C ( Department of Microbiology, School of Biomedical Sciences, Monash University, Victoria, Australia.); Baumert TF ( Inserm U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France) |
| Abstract | Hepatitis C virus (HCV) infection relies on virus–host interactions with human hepatocytes, a context in which host cell kinases play critical roles in every step of the HCV life cycle. During viral entry, cellular kinases, including EGFR, EphA2 and PKA, regulate the localization of host HCV entry factors and induce receptor complex assembly. Following virion internalization, viral genomes replicate on endoplasmic reticulum-derived membranous webs. The formation of membranous webs depends on interactions between the HCV NS5a protein and PI4KIIIα. The phosphorylation status of NS5a, regulated by PI4KIIIα, CKI and other kinases, also acts as a molecular switch to virion assembly, which takes place on lipid droplets. The formation of lipid droplets is enhanced by HCV activation of IKKα. In view of the multiple crucial steps in the viral life cycle that are mediated by host cell kinases, these enzymes also represent complementary targets for antiviral therapy. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Part | Pt B |
| Issue Number | 10 |
| Volume Number | 1854 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-10-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Hepacivirus Genetics Hepatitis C Host-Pathogen Interactions Receptor, Epidermal Growth Factor Metabolism Animals Pathogenicity Virology Hepatocytes Enzymology Life Cycle Stages Minor Histocompatibility Antigens Phosphotransferases (Alcohol Group Acceptor) Receptor, EphA2 Viral Nonstructural Proteins Virus Assembly Virus Internalization Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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